22:T4ef,Designing and implementing means of locally trapping magnetic beads and understanding the factors underlying the bead capture force are important steps toward advancing the capture-release process of magnetic particles for biological applications. In particular, capturing magnetically labeled cells using magnetic microstructures with perpendicular magnetic anisotropy (PMA) will enable an approach to cell manipulation for emerging lab-on-a-chip devices. Here, a Co (0.2 nm)/Ni (0.4 nm) multilayered structure was designed to exhibit strong PMA and large saturation magnetization (M _s ). Finite element simulations were performed to assess the dependence of the capture force on the value of M _s . The simulated force profile indicated the largest force at the perimeter of the disks. Arrays of Co/Ni disk structures of (4-7) μm diameter were fabricated and tested in a microchannel with suspended fluorescent magnetic beads. The magnetic beads were captured and localized to the edge of the disks as predicted by the simulations. This approach has been demonstrated to enable uniform assembly of magnetic beads without external fields and may provide a pathway toward precise cell manipulation methods.23:T416,Abstract Precise control and manipulation of nano-beads have various applications, e.g. cell sorter, 3D printing and nano-motors. In this paper we present an approach in which we use voltage on a piezolecetric substrate in order to reorient the magnetization of a nano-disk. In turn this magnetization drives the dynamic of the nano-beads. This is an energy efficient method to control the nano-beads motion since only voltage is applied to the substrate. The mechanism consists of a Ni disk and three pairs of surface electrodes placed on a PZT substrate. By controlling the voltage applied on the different pairs of electrodes, the magnetization of the Ni disk will rotate with constant angular velocity. The rotating magnetization will then generate magnetic force on the soft-magnetic nano-beads driving the motion. For the beads, full 3D dynamics consider both translation and rotation and the forces considered are magnetic, drag, friction and adhesion. With this model we are able to have a realistic description for the particle behavior.

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