Ming‐Der Perng

Glial Fibrillary Acidic Protein Filaments Can Tolerate the Incorporation of Assembly-compromised GFAP-δ, but with Consequences for Filament Organization and αB-Crystallin Association

Ming‐Der Perng, Shu‐Fang Wen, Terry Gibbon et al. · Molecular Biology of the Cell · 2008 · 105 citations · Full text

Site-specific phosphorylation and caspase cleavage of GFAP are new markers of Alexander disease severity

Rachel A. Battaglia, Adriana S. Beltrán, Samed Delic et al. · eLife · 2019 · 67 citations · Full text

Immunology, Cell Death, Pathology +24

Caspase Cleavage of GFAP Produces an Assembly-Compromised Proteolytic Fragment that Promotes Filament Aggregation

Mei-Hsuan Chen, Tracy L. Hagemann, Roy A. Quinlan et al. · ASN NEURO · 2013 · 56 citations · Full text

Protein Assembly, Normal Filament Assembly, Intermediate Filament +22

Antisense therapy in a rat model of Alexander disease reverses GFAP pathology, white matter deficits, and motor impairment

Tracy L. Hagemann, Berit Powers, Ni‐Hsuan Lin et al. · Science Translational Medicine · 2021 · 51 citations · Full text

Alexander disease causing mutations in the C-terminal domain of GFAP are deleterious both to assembly and network formation with the potential to both activate caspase 3 and decrease cell viability

Suh-Ciuan Lim, Mei-Hsuan Chen, Roy A. Quinlan et al. · Experimental Cell Research · 2011 · 41 citations · Full text

Signal Transduction, Signaling Pathway, Disease Mechanism +12