Salicylate Biosynthesis: Overexpression, Purification, and Characterization of Irp9, a Bifunctional Salicylate Synthase from<i>Yersinia enterocolitica</i>

Olivier Kerbarh, Alessio Ciulli, Nigel Howard, +1

Journal of Bacteriology

BiosynthesisEngineeringBiochemistryMedicineVirulence Factor +13

Crystal Structures of Yersinia enterocolitica Salicylate Synthase and its Complex with the Reaction Products Salicylate and Pyruvate

Olivier Kerbarh, Dimitri Y. Chirgadze, Tom L. Blundell, +1

Journal of Molecular Biology

Reaction Products SalicylateBiosynthesisBiochemistryNatural SciencesBiocatalysis +8

Crystal Structure of Escherichia coli Enterobactin-specific Isochorismate Synthase (EntC) Bound to its Reaction Product Isochorismate: Implications for the Enzyme Mechanism and Differential Activity of Chorismate-utilizing Enzymes

Sudharsan Sridharan, Nigel Howard, Olivier Kerbarh, +3

Journal of Molecular Biology

Crystal StructureEnzyme MechanismBiochemistryNatural SciencesBiocatalysis +7

Mechanism of α-oxoamine synthases: identification of the intermediate Claisen product in the 8-amino-7-oxononanoate synthase reaction

Olivier Kerbarh, Dominic J. Campopiano, Robert L. Baxter

Chemical Communications

BiosynthesisBioorganic Chemistryα-Oxoamine SynthasesBiochemistryAldo-keto Reductase +13

Suicide inhibition of α-oxamine synthases: structures of the covalent adducts of 8-amino-7-oxononanoate synthase with trifluoroalanine

Dmitry Alexeev, Robert L. Baxter, Dominic J. Campopiano, +5

Organic & Biomolecular Chemistry

Suicide InhibitionChemical BiologyEnzymatic ModificationPharmaceutical ChemistryMedicinal Chemistry +15

Rational Design, Synthesis, and Evaluation of Nanomolar Type II Dehydroquinase Inhibitors

Richard J. Payne, Fabienne Peyrot, Olivier Kerbarh, +2

ChemMedChem

Inhibition studies on salicylate synthase

Richard J. Payne, Olivier Kerbarh, Ricardo Núñez Miguel, +2

Organic & Biomolecular Chemistry

Inhibitory ActivityMedicinal ChemistryPharmaceutical ChemistryBioorganic ChemistryBiochemistry +10

Long-Lasting Enfuvirtide Carrier Pentasaccharide Conjugates with Potent Anti-Human Immunodeficiency Virus Type 1 Activity

Thierry Huet, Olivier Kerbarh, Dominique Schols, +11

Antimicrobial Agents and Chemotherapy

Medicinal ChemistryEfficient Anti-hiv-1 DrugMedicineHuman RetrovirusImmunology +11

Synthesis and evaluation of 2,5-dihydrochorismate analogues as inhibitors of the chorismate-utilising enzymes

Richard J. Payne, Esther M. M. Bulloch, Miguel M. Toscano, +3

Organic & Biomolecular Chemistry

Chorismate-utilising EnzymesMedicinal ChemistryBiosynthesisBioorganic ChemistryIsochorismate Synthase +13

Nanomolar Inhibition of Type II Dehydroquinase Based on the Enolate Reaction Mechanism

Miguel D. Toscano, Richard J. Payne, Akira Chibá, +2

ChemMedChem