Frank Wesche

De novo design and engineering of non-ribosomal peptide synthetases

Kenan A. J. Bozhüyük, Florian Fleischhacker, Annabell Linck et al. · Nature Chemistry · 2017 · 225 citations

Life Sciences, Biotechnology, Molecular Biology +10

Modification and de novo design of non-ribosomal peptide synthetases using specific assembly points within condensation domains

Kenan A. J. Bozhüyük, Annabell Linck, Andreas Tietze et al. · Nature Chemistry · 2019 · 180 citations

Life Sciences, Biochemistry, Molecular Biology +11

Entomopathogenic bacteria use multiple mechanisms for bioactive peptide library design

Xiaofeng Cai, Sarah A. Nowak, Frank Wesche et al. · Nature Chemistry · 2016 · 108 citations

Life Sciences, Biotechnology, Microbiology +14

Promoter Activation in Δ<i>hfq</i> Mutants as an Efficient Tool for Specialized Metabolite Production Enabling Direct Bioactivity Testing

Edna Bode, Antje K. Heinrich, Merle Hirschmann et al. · Angewandte Chemie International Edition · 2019 · 73 citations · Full text

Life Sciences, Biotechnology, Molecular Biology +14

Efficient nonenzymatic cyclization and domain shuffling drive pyrrolopyrazine diversity from truncated variants of a fungal NRPS

Daniel Berry, Wade J. Mace, Katrin Grage et al. · Proceedings of the National Academy of Sciences · 2019 · 41 citations · Full text

Pharmacy, Biochemistry, Biotechnology +14