Takao Mandai

TAK-071, a novel M1 positive allosteric modulator with low cooperativity, improves cognitive function in rodents with few cholinergic side effects

Yuu Sako, Emi Kurimoto, Takao Mandai et al. · Neuropsychopharmacology · 2018 · 55 citations · Full text

Life Sciences, Neuroscience, Pharmacology +17

An Approach to Discovering Novel Muscarinic M1 Receptor Positive Allosteric Modulators with Potent Cognitive Improvement and Minimized Gastrointestinal Dysfunction

Emi Kurimoto, Satoru Matsuda, Yūji Shimizu et al. · Journal of Pharmacology and Experimental Therapeutics · 2017 · 30 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15

In Vivo Pharmacological Comparison of TAK-071, a Positive Allosteric Modulator of Muscarinic M1 Receptor, and Xanomeline, an Agonist of Muscarinic M1/M4 Receptor, in Rodents

Takao Mandai, Maki Kasahara, Emi Kurimoto et al. · Neuroscience · 2019 · 19 citations

Medicine, Medicinal Chemistry, Pharmacology +15

T‐495, a novel low cooperative M₁ receptor positive allosteric modulator, improves memory deficits associated with cholinergic dysfunction and is characterized by low gastrointestinal side effect risk

Takao Mandai, Yuu Sako, Emi Kurimoto et al. · Pharmacology Research & Perspectives · 2020 · 14 citations · Full text

Medicine, Neuroscience, Pharmacology +17