Christopher Negron

Predicting the Effect of Amino Acid Single-Point Mutations on Protein Stability—Large-Scale Validation of MD-Based Relative Free Energy Calculations

Thomas Steinbrecher, Chongkai Zhu, Lingle Wang et al. · Journal of Molecular Biology · 2016 · 113 citations

Protein Chemistry, Biochemistry, Protein Folding +8

Relative Binding Affinity Prediction of Charge-Changing Sequence Mutations with FEP in Protein–Protein Interfaces

Anthony Clark, Christopher Negron, Kevin Hauser et al. · Journal of Molecular Biology · 2019 · 104 citations · Full text

Predicting resistance of clinical Abl mutations to targeted kinase inhibitors using alchemical free-energy calculations

Kevin Hauser, Christopher Negron, Steven K. Albanese et al. · Communications Biology · 2018 · 100 citations · Full text

A Set of Computationally Designed Orthogonal Antiparallel Homodimers that Expands the Synthetic Coiled-Coil Toolkit

Christopher Negron, Amy E. Keating · Journal of the American Chemical Society · 2014 · 64 citations · Full text

Engineering, Coiled-coil Drug Delivery, Protein Assembly +14

Large‐scale in vitro functional testing and novel variant scoring via protein modeling provide insights into alkaline phosphatase activity in hypophosphatasia

Guillermo del Angel, John Reynders, Christopher Negron et al. · Human Mutation · 2020 · 54 citations · Full text

Genetics, Molecular Biology, Disease Gene Identification +21