Roy Nijhuis

Unbiased Combinatorial Screening Identifies a Bispecific IgG1 that Potently Inhibits HER3 Signaling via HER2-Guided Ligand Blockade

Cecile Geuijen, Camilla De Nardis, David Maussang et al. · Cancer Cell · 2018 · 105 citations · Full text

Signal Transduction, Signaling Pathway, Receptor Tyrosine Kinase +8

Generation of stable cell clones expressing mixtures of human antibodies

John de Kruif, Arjen Kramer, Roy Nijhuis et al. · Biotechnology and Bioengineering · 2010 · 38 citations

Human Immunoglobulin Repertoires against Tetanus Toxoid Contain a Large and Diverse Fraction of High-Affinity Promiscuous VH Genes

John de Kruif, Arjen Kramer, Therèse Visser et al. · Journal of Molecular Biology · 2009 · 25 citations

Immunogenetics, Autoimmune Disease, Medicine +11

Preclinical activity of MCLA-128, an ADCC enhanced bispecific IgG1 antibody targeting the HER2:HER3 heterodimer.

Cecile Geuijen, Eric Rovers, Roy Nijhuis et al. · Journal of Clinical Oncology · 2014 · 18 citations

Immunology, Immunotherapy, Cancer Biology +19