Jodi Moriguchi

Therapeutic Antibody Targeting Tumor- and Osteoblastic Niche-Derived Jagged1 Sensitizes Bone Metastasis to Chemotherapy

Hanqiu Zheng, Yangjin Bae, Sabine Kasimir‐Bauer et al. · Cancer Cell · 2017 · 158 citations · Full text

Medicine, Oncology, Pharmacology +12

Discovery and Optimization of Triazolopyridazines as Potent and Selective Inhibitors of the c-Met Kinase

Brian K. Albrecht, Jean-Christophe Harmange, David Bauer et al. · Journal of Medicinal Chemistry · 2008 · 139 citations · Full text

Medicine, Medicinal Chemistry, Oncology +14

c-Met Inhibitors with Novel Binding Mode Show Activity against Several Hereditary Papillary Renal Cell Carcinoma-related Mutations

Steven F. Bellon, Paula Kaplan‐Lefko, Yajing Yang et al. · Journal of Biological Chemistry · 2007 · 138 citations · Full text

Medicine, Oncology, Pharmacology +13

Conatumumab, a fully human agonist antibody to death receptor 5, induces apoptosis via caspase activation in multiple tumor types

Paula Kaplan‐Lefko, Jonathan D. Graves, Stephen J. Zoog et al. · Cancer Biology & Therapy · 2010 · 126 citations · Full text

Life Sciences, Oncology, Pharmacology +17

Discovery of a Potent, Selective, and Orally Bioavailable c-Met Inhibitor: 1-(2-Hydroxy-2-methylpropyl)-<i>N</i>-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1<i>H</i>-pyrazole-4-carboxamide (AMG 458)

Longbin Liu, Aaron Siegmund, Ning Xi et al. · Journal of Medicinal Chemistry · 2008 · 95 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14