21:I[432972,["/_next/static/chunks/bb923814e1f4d2e9.js","/_next/static/chunks/dd3ee9f5b7716ca6.js","/_next/static/chunks/4204a0ae82542ca8.js","/_next/static/chunks/1270dead247da766.js","/_next/static/chunks/6e1aa89a642f40be.js","/_next/static/chunks/2d7aa753e81324a8.js","/_next/static/chunks/8ffd0b71567920d8.js","/_next/static/chunks/67ea6dfd21f16c5f.js","/_next/static/chunks/24eb4379f68013fd.js","/_next/static/chunks/b8cd775ffdf935bd.js","/_next/static/chunks/983103cd9eb7b428.js","/_next/static/chunks/263f2cdcb9aa2341.js","/_next/static/chunks/294b9525248c8e5f.js"],"default"] 22:T40b,Emerging moisture sensitive devices require robust encapsulation strategies to inhibit water ingress and prevent premature failure. A scalable, open-air plasma process has been developed to deposit alternating layers of conformal organosilicate and dense SiO₂ thin-film barriers to prevent moisture ingress. The in situ low-temperature process is suitable for direct deposition on thermally sensitive devices and is compatible with flexible polymeric substrates. Using optical calcium testing, low water vapor transmission rates on the order of 10^-3 g/m²/day at an accelerated aging condition of 38 °C and 90% relative humidity (RH) are achieved. Using moisture-sensitive perovskite devices as a representative moisture-susceptible device, devices retain over 80% of their initial performance for over 660 h in a 50 °C 50% RH accelerated aging environment. The ability of the multilayer barrier to enable device resistance to humid environments is crucial toward realizing longer operating lifetimes.23:T4c4,Poly(lactic-co-glycolic acid) (PLGA) based biomaterials have many advantages and potential applications in bone tissue engineering. Whereas, a significant problem which could not be ignored was that the acidic by-products generated during its degradation induced severe inflammatory reactions and negatively regulated bone regeneration. In this research, feasibility of using dexamethasone (Dex) to improve the biocompatibility of PLGA is investigated in detail. Hereby, various contents of PLGA/hydroxyapatite (PH) nanofibers loaded with Dex were synthesized by electrospinning technique. It was shown that 0.5% (wt) Dex in PH scaffolds was the minimum content which was required for anti-inflammatory effect. Admittedly, Dex to some extent had cytotoxic effect on osteoblasts and an inhibitory effect on ALP activity in this study; nevertheless, the relatively low Dex (<2% [wt]) had no inhibitory effects on osteoblasts maturation and mineralization. By this token, Dex is a good candidate for improving biocompatibility of PLGA based biomaterials. Moreover, the cytotoxic effects of Dex should be concerned. This study will provide a rationale for optimizing biocompatibility of PLGA based biomaterials by using Dex.24:T41a,Strontium-containing agents have been demonstrated to elicit both bone anabolic and antiosteoporotic effects, showing great potential for the treatment of bone loss. However, an increased incidence of strontium-induced side effects restricts their clinical applications. Herein, oxidized carbon nitride nanosheets (CN) are delicately used to incorporate Sr²⁺ for the first time to achieve high osteogenic efficacy. The lamellar structure and enriched nitrogen species of CN provide them with a high surface area-to-volume ratio and abundant anchoring sites for Sr²⁺ incorporation. Importantly, Sr²⁺-incorporated CN (CNS) could synergistically promote osteoblast differentiation and bone regeneration at a single, very low Sr²⁺ dose. Mechanically, CNS could activate the FAK/RhoA signaling pathway to modulate the intracellular tension that stimulates osteoblasts differentiation. The present study will provide a new paradigm to enhance the efficacy of osteogenic metal ions by using lamellar nanocarriers.

#	Concept	H-Index	Publications	Citations
1	Medicine	2	2	317
2	Engineering	1	1	22
3	Biomedical Engineering	1	1	22
4	Cell Biology	1	1	295
5	Immunology	1	1	295

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