Discovery of S-217622, a Noncovalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19

Yuto Unoh, Shota Uehara, Kenji Nakahara, +22

Journal of Medicinal Chemistry

SARS-CoV-2 variants with mutations at the S1/S2 cleavage site are generated in vitro during propagation in TMPRSS2-deficient cells

Michihito Sasaki, Kentaro Uemura, Akihiko Sato, +6

PLoS Pathogens

S Gene MutationsSars-cov-2 VariantsViral EvolutionVirus VariantsMedicine +11

S-217622, a SARS-CoV-2 main protease inhibitor, decreases viral load and ameliorates COVID-19 severity in hamsters

Michihito Sasaki, Koshiro Tabata, Mai Kishimoto, +19

Science Translational Medicine

Lipoprotein Receptors Redundantly Participate in Entry of Hepatitis C Virus

Satomi Yamamoto, Takasuke Fukuhara, Chikako Ono, +12

PLoS Pathogens

Hepatitis C VirusImmunologyViral PathogenesisPathologyViral Hepatitis +16

TMPRSS11D and TMPRSS13 Activate the SARS-CoV-2 Spike Protein

Mai Kishimoto, Kentaro Uemura, Takao Sanaki, +6

Viruses

Virus StructureTmprss13 ActivateViral ReplicationSignal TransductionSerine 2 +12

Computed tomography of cerebral infarction along the distribution of the basal perforating arteries. Part II: Thalamic arterial group.

Sayuri Takahashi, K Goto, Hiroko Fukasawa, +3

Radiology

Cerebrovascular DiseaseThalamogeniculate ArteriesThalamic Arterial GroupCerebral AngiographyNeurovascular Disease +18

Enhanced permeability of tetragastrin across the rat intestinal membrane and its reduced degradation by acylation with various fatty acids.

Etsuo Yodoya, Kentaro Uemura, Takehiro Tenma, +4

Journal of Pharmacology and Experimental Therapeutics

Discovery of S-217622, a Non-Covalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19

Yuto Unoh, Shota Uehara, Kenji Nakahara, +22

Coronavirus Disease 2019Molecular PharmacologyMedicinal ChemistryVirtual ScreeningMedicine +13

Photoinduced Formation of Wrinkled Microstructures with Long‐Range Order in Thin Oxide Films

Masahide Takahashi, Takuya Maeda, Kentaro Uemura, +6

Advanced Materials

EngineeringMicro-optical ComponentLong-range OrderChemical EngineeringPhotopolymer Network +16

SARS-CoV-2 Bearing a Mutation at the S1/S2 Cleavage Site Exhibits Attenuated Virulence and Confers Protective Immunity

Michihito Sasaki, Shinsuke Toba, Yukari Itakura, +10

mBio