Joel R. Calvin

Development and Scale-Up of a Continuous, High-Pressure, Asymmetric Hydrogenation Reaction, Workup, and Isolation

Martin D. Johnson, Scott A. May, Joel R. Calvin et al. · Organic Process Research & Development · 2012 · 148 citations

Engineering, Chemical Engineering, Process Safety +16

Kilogram-Scale GMP Manufacture of Tirzepatide Using a Hybrid SPPS/LPPS Approach with Continuous Manufacturing

Michael O. Frederick, Raymond A. Boyse, Timothy M. Braden et al. · Organic Process Research & Development · 2021 · 84 citations

Engineering, Biotechnology, Chemical Engineering +17

Rapid Development and Scale-Up of a 1<i>H</i>-4-Substituted Imidazole Intermediate Enabled by Chemistry in Continuous Plug Flow Reactors

Scott A. May, Martin D. Johnson, Timothy M. Braden et al. · Organic Process Research & Development · 2012 · 74 citations

Engineering, Chemistry, Medicinal Chemistry +15

Rhodium-Catalyzed and Zinc(II)-Triflate-Promoted Asymmetric Hydrogenation of Tetrasubstituted α,β-Unsaturated Ketones

Joel R. Calvin, Michael O. Frederick, Dana L. T. Laird et al. · Organic Letters · 2012 · 62 citations

Natural Sciences, Chemical Engineering, Chemistry +15

Continuous Liquid Vapor Reactions Part 2: Asymmetric Hydroformylation with Rhodium-Bisdiazaphos Catalysts in a Vertical Pipes-in-Series Reactor

M. Leigh Abrams, Jonas Y. Buser, Joel R. Calvin et al. · Organic Process Research & Development · 2016 · 45 citations

Engineering, Chemical Engineering, Chemistry +17