The autoimmune disease–associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness

Jinyi Zhang, Naima Zahir, Qiuhong Jiang, +11

Nature Genetics

InflammationCalpain-mediated Lyp/pep DegradationSignal TransductionAutoimmune DiseaseDendritic Cell Hyperresponsiveness +11

Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia

Denis E. Reyna, Thomas P. Garner, Andrea López, +11

Cancer Cell

Hematological MalignancyMixed-phenotype Acute LeukemiaAcute Myeloid LeukemiaApoptosisImmunology +7

The mDial Formin Is Required for Neutrophil Polarization, Migration, and Activation of the LARG/RhoA/ROCK Signaling Axis during Chemotaxis

Yongquan Shi, Jinyi Zhang, Michael Mullin, +3

The Journal of Immunology

Signal TransductionNeutrophil PolarizationCell TraffickingImmunologyLarg/rhoa/rock Signaling Axis +13

Targeting Autophagy Augments <i>In Vitro</i> and <i>In Vivo</i> Antimyeloma Activity of DNA-Damaging Chemotherapy

Yaozhu Pan, Ying Gao, Liang Chen, +5

Clinical Cancer Research

Dysregulation of unfolded protein response partially underlies proapoptotic activity of bortezomib in multiple myeloma cells

Hongjuan Dong, Liang Chen, Xiequn Chen, +4

Leukemia & lymphoma/Leukemia and lymphoma

Hematological MalignancyMedicineApoptosisImmunologyUnfolded Protein Response +13

N-WASp is required for Schwann cell cytoskeletal dynamics, normal myelin gene expression and peripheral nerve myelination

Fuzi Jin, Baoxia Dong, John Georgiou, +12

Development

NeuroregenerationMolecular NeuroscienceDevelopmental BiologyMyelin FormationCellular Neurobiology +13

Clinical Results of a Multicenter Study of the First-in-Human Dual BCMA and CD19 Targeted Novel Platform Fast CAR-T Cell Therapy for Patients with Relapsed/Refractory Multiple Myeloma

Hua Jiang, Baoxia Dong, Li Gao, +22

Blood

Biochemical and Genetic Evidence for a SAP-PKC-θ Interaction Contributing to IL-4 Regulation

Jennifer L. Cannons, Julie Z. Wu, Julio Gómez‐Rodríguez, +6

The Journal of Immunology

T-regulatory CellImmune RegulationImmunologyImmunologic MechanismCd4 T Cell Responses +18

Updated results of a phase I, open-label study of BCMA/CD19 dual-targeting fast CAR-T GC012F for patients with relapsed/refractory multiple myeloma (RRMM).

Juan Du, Weijun Fu, Hua Jiang, +16

Journal of Clinical Oncology

Cell TherapyMedian DurationImmunologyTransplantation MedicineImmunodominance +21

Increased expression of TIGIT on CD4⁺T cells ameliorates immune-mediated bone marrow failure of aplastic anemia

Tao Zhang, Jianhong Wang, Xingchun Zhou, +8

Journal of Cellular Biochemistry

Clinical ImmunologyLymphocyte DevelopmentAdaptive Immune SystemT-regulatory CellImmune Regulation +22