George Kemble

Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gene Expression

Richard Ventura, Kasia Mordec, Joanna Waszczuk et al. · EBioMedicine · 2015 · 296 citations · Full text

Life Sciences, Oncology, Pharmacology +17

First-in-human study of the safety, pharmacokinetics, and pharmacodynamics of first-in-class fatty acid synthase inhibitor TVB-2640 alone and with a taxane in advanced tumors

Gerald S. Falchook, Jeffrey R. Infante, Hendrik‐Tobias Arkenau et al. · EClinicalMedicine · 2021 · 275 citations · Full text

Medicine, Oncology, Pharmacology +14

TVB-2640 (FASN Inhibitor) for the Treatment of Nonalcoholic Steatohepatitis: FASCINATE-1, a Randomized, Placebo-Controlled Phase 2a Trial

Rohit Loomba, Rizwana Mohseni, Kathryn Jean Lucas et al. · Gastroenterology · 2021 · 217 citations · Full text

Medicine, Internal Medicine, Pharmacology +11

Persistent and Selective Deficiency of CD4+ T Cell Immunity to Cytomegalovirus in Immunocompetent Young Children

Wenwei Tu, Sharon Chen, Margaret Sharp et al. · The Journal of Immunology · 2004 · 201 citations · Full text

Life Sciences, Immunology, Microbiology +17

Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer

Caterina Bartolacci, Cristina Andreani, Gonçalo Vale et al. · Nature Communications · 2022 · 170 citations · Full text

Life Sciences, Molecular Biology, Oncology +17