João Leandro

DHTKD1 and OGDH display substrate overlap in cultured cells and form a hybrid 2-oxo acid dehydrogenase complex in vivo

João Leandro, Tetyana Dodatko, Jan Aten et al. · Human Molecular Genetics · 2020 · 35 citations · Full text

Life Sciences, Biochemistry, Cell Biology +14

Co-expression of different subunits of human phenylalanine hydroxylase: Evidence of negative interallelic complementation

João Leandro, Cátia Nascimento, Isabel Tavares de Almeida et al. · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 2006 · 34 citations

Life Sciences, Genetics, Molecular Genetics +14

Phenylketonuria as a protein misfolding disease: The mutation pG46S in phenylalanine hydroxylase promotes self-association and fibril formation

João Leandro, Nina Simonsen, Jaakko Saraste et al. · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 2010 · 31 citations · Full text

Life Sciences, Biochemistry, Genetics +15

Deletion of 2‐aminoadipic semialdehyde synthase limits metabolite accumulation in cell and mouse models for glutaric aciduria type 1

João Leandro, Tetyana Dodatko, Robert J. DeVita et al. · Journal of Inherited Metabolic Disease · 2020 · 30 citations

Life Sciences, Biochemistry, Cellular Metabolism +10

Heterotetrameric forms of human phenylalanine hydroxylase: Co-expression of wild-type and mutant forms in a bicistronic system

João Leandro, Paula Leandro, Torgeir Flatmark · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 2011 · 29 citations

Life Sciences, Biochemistry, Molecular Biology +14