Stefano Giustino Manzo

DNA damage and genome instability by G-quadruplex ligands are mediated by R loops in human cancer cells

Alessio De Magis, Stefano Giustino Manzo, Marco Russo et al. · Proceedings of the National Academy of Sciences · 2018 · 348 citations

Life Sciences, Molecular Biology, Oncology +17

Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance

Ruben Schep, Eva K. Brinkman, Christ Leemans et al. · Molecular Cell · 2021 · 211 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

DNA Topoisomerase I differentially modulates R-loops across the human genome

Stefano Giustino Manzo, Stella R. Hartono, Lionel A. Sanz et al. · Genome biology · 2018 · 151 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Natural Product Triptolide Mediates Cancer Cell Death by Triggering CDK7-Dependent Degradation of RNA Polymerase II

Stefano Giustino Manzo, Zhaoli Zhou, Ying-Qing Wang et al. · Cancer Research · 2012 · 111 citations · Full text

Medicine, Oncology, Pharmacology +17

Antisense transcripts enhanced by camptothecin at divergent CpG-island promoters associated with bursts of topoisomerase I-DNA cleavage complex and R-loop formation

Jessica Marinello, Giovanni Chillemi, Susana Bueno et al. · Nucleic Acids Research · 2013 · 79 citations · Full text

Life Sciences, Genetics, Molecular Biology +13