R. Michael Lawrence

Ligand and Target Discovery by Fragment-Based Screening in Human Cells

Christopher G. Parker, Andrea Galmozzi, Yujia Wang et al. · Cell · 2017 · 462 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Cancer Cell Dependence on Unsaturated Fatty Acids Implicates Stearoyl-CoA Desaturase as a Target for Cancer Therapy

Urvashi V. Roongta, Jonathan G. Pabalan, Xinyu Wang et al. · Molecular Cancer Research · 2011 · 278 citations

Life Sciences, Cancer Biology, Oncology +17

An MTP Inhibitor That Normalizes Atherogenic Lipoprotein Levels in WHHL Rabbits

John R. Wetterau, Richard E. Gregg, Thomas Harrity et al. · Science · 1998 · 269 citations

Life Sciences, Medicinal Chemistry, Pharmacology +17

Expedited mapping of the ligandable proteome using fully functionalized enantiomeric probe pairs

Yujia Wang, Melissa M. Dix, Giulia Bianco et al. · Nature Chemistry · 2019 · 193 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +8

Blockade of protease-activated receptor-4 (PAR4) provides robust antithrombotic activity with low bleeding

Pancras C. Wong, Dietmar Seiffert, J. Eileen Bird et al. · Science Translational Medicine · 2017 · 149 citations

Medicine, Medicinal Chemistry, Pharmacology +14