A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets

Niantao Deng, Liang Kee Goh, Hannah Wang, +26

Gut

Molecular correlates of clinical response and resistance to atezolizumab in combination with bevacizumab in advanced hepatocellular carcinoma

Andrew X. Zhu, Alexander R. Abbas, Marina Ruiz de Galarreta, +17

Nature Medicine

MedicineImmunologyMolecular CorrelatesPathologyImmune Checkpoint Inhibitor +7

Interaction between tumour-infiltrating B cells and T cells controls the progression of hepatocellular carcinoma

Marta Garnelo, Alex Y. Tan, Zhisheng Her, +15

Gut

Atezolizumab plus bevacizumab versus active surveillance in patients with resected or ablated high-risk hepatocellular carcinoma (IMbrave050): a randomised, open-label, multicentre, phase 3 trial

Shukui Qin, Minshan Chen, Ann‐Lii Cheng, +202

The Lancet

Surgical OncologyHepatologyMedicinePathologyHigh-risk Hepatocellular Carcinoma +6

Chemokine-driven lymphocyte infiltration: an early intratumoural event determining long-term survival in resectable hepatocellular carcinoma

Valerie Chew, Jinmiao Chen, Deming Lee, +13

Gut

Intrinsic Subtypes of Gastric Cancer, Based on Gene Expression Pattern, Predict Survival and Respond Differently to Chemotherapy

Iain Beehuat Tan, Tatiana Ivanova, Kiat Hon Lim, +24

Gastroenterology

Intrinsic SubtypesTumor BiologyTumor HeterogeneityMedicineGene Expression Pattern +9

Multidimensional analyses reveal distinct immune microenvironment in hepatitis B virus-related hepatocellular carcinoma

Chun Jye Lim, Yun Hua Lee, Lu Pan, +15

Gut

ImmunologyHepatitis BPathologyImmunotherapeuticsImmune System +21

Epstein-Barr Virus-Associated Smooth Muscle Tumors Are Distinctive Mesenchymal Tumors Reflecting Multiple Infection Events

Andrea T. Deyrup, Victor Kwan Min Lee, Charles E. Hill, +5

The American Journal of Surgical Pathology

Ebv Type 2Diagnostic VirologyHistopathologyImmunologyPathology +7

Loss of BCAA Catabolism during Carcinogenesis Enhances mTORC1 Activity and Promotes Tumor Development and Progression

Russell Ericksen, Siew Lan Lim, Eoin McDonnell, +10

Cell Metabolism

Tumor BiologyPromotes Tumor DevelopmentOncogenic AgentMedicineBcaa Catabolism +6

Inflammatory tumour microenvironment is associated with superior survival in hepatocellular carcinoma patients

Valerie Chew, Charlene Tow, Marissa Teo, +11

Journal of Hepatology

HepatologyHepatocellular Carcinoma PatientsHepatocellular CarcinomaMedicineImmunology +8