Rezaul M. Karim

Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon

Afua A. Akuffo, Aileen Y. Alontaga, Rainer Metcalf et al. · Journal of Biological Chemistry · 2018 · 56 citations · Full text

Medicine, Molecular Biology, Oncology +13

Targeting the BRD4-HOXB13 Coregulated Transcriptional Networks with Bromodomain-Kinase Inhibitors to Suppress Metastatic Castration-Resistant Prostate Cancer

Niveditha Nerlakanti, Jiqiang Yao, Duy T. Nguyen et al. · Molecular Cancer Therapeutics · 2018 · 35 citations · Full text

Medicine, Molecular Biology, Oncology +17

Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains

Rezaul M. Karim, A. Chan, J. Zhu et al. · Journal of Medicinal Chemistry · 2020 · 32 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +13

Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain

Rezaul M. Karim, Leixiang Yang, Lihong Chen et al. · Journal of Medicinal Chemistry · 2022 · 25 citations · Full text

Life Sciences, Molecular Biology, Oncology +17

Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors

Rezaul M. Karim, Melissa J. Bikowitz, A. Chan et al. · Journal of Medicinal Chemistry · 2021 · 23 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14