Lise Van Wyngene

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile

Karen Dendoncker, Steven Timmermans, Jolien Vandewalle et al. · Proceedings of the National Academy of Sciences · 2019 · 81 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Combined glucocorticoid resistance and hyperlactatemia contributes to lethal shock in sepsis

Jolien Vandewalle, Steven Timmermans, Ville Paakinaho et al. · Cell Metabolism · 2021 · 75 citations · Full text

Veterinary Medicine, Immunology, Physiology +14

Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice

Marlies Ballegeer, Kelly Van Looveren, Steven Timmermans et al. · Journal of Clinical Investigation · 2018 · 71 citations · Full text

Life Sciences, Immunology, Molecular Biology +17

Hepatic PPARα function and lipid metabolic pathways are dysregulated in polymicrobial sepsis

Lise Van Wyngene, Tineke Vanderhaeghen, Steven Timmermans et al. · EMBO Molecular Medicine · 2020 · 70 citations · Full text

Veterinary Medicine, Biochemistry, Pharmacology +17

A screening assay for Selective Dimerizing Glucocorticoid Receptor Agonists and Modulators (SEDIGRAM) that are effective against acute inflammation

Jolien Souffriau, Melanie Eggermont, Sara Van Ryckeghem et al. · Scientific Reports · 2018 · 23 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17