Correlation Between Oral Drug Absorption in Humans, and Apparent Drug Permeability in TC-7 Cells, A Human Epithelial Intestinal Cell Line: Comparison with the Parental Caco-2 Cell Line

Marie‐Catherine Grès, Bernard Julian, Martine Bourrié, +6

Pharmaceutical Research

Pharmacokinetic assessment of a five‐probe cocktail for CYPs 1A2, 2C9, 2C19, 2D6 and 3A

Sandrine Turpault, William R. Brian, Robert Van Horn, +4

British Journal of Clinical Pharmacology

Characterisation of a newly isolated Caco-2 clone (TC-7), as a model of transport processes and biotransformation of drugs

Isabelle Caro, Xavier Boulenc, Monique Rousset, +8

International Journal of Pharmaceutics

BiotransformationBiochemistryCaco-2 CloneMedicineMembrane Transport +4

Importance of the paracellular pathway for the transport of a new bisphosphonate using the human CACO-2 monolayers model

Xavier Boulenc, E. Martì, H Joyeux, +3

Biochemical Pharmacology

Proteinlipid InteractionMembrane FormationSignal TransductionBiochemistryMedicine +6

Regulation of cytochrome P450IA1 gene expression in a human intestinal cell line, Caco-2.

Xavier Boulenc, Martine Bourrié, Isabelle Fabre, +4

Journal of Pharmacology and Experimental Therapeutics

Physiologically Based Pharmacokinetic Modeling for Sequential Metabolism: Effect of CYP2C19 Genetic Polymorphism on Clopidogrel and Clopidogrel Active Metabolite Pharmacokinetics

Nassim Djebli, David Fabre, Xavier Boulenc, +3

Drug Metabolism and Disposition

The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to <i>Plasmodium falciparum</i> parasite resistance

James M. Murithi, Cécile Pascal, Jade Bath, +52

Science Translational Medicine

Purification of two cytochrome <i>P</i>450 isozymes related to CYP2A and CYP3A gene families from monkey (baboon, <i>Papio papio</i>) liver microsomes

Isabelle Dalet-Beluche, Xavier Boulenc, Gérard Fabre, +2

European Journal of Biochemistry

IMI – oral biopharmaceutics tools project – evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds

Alison Margolskee, Adam S. Darwich, Xavier Pépin, +43

European Journal of Pharmaceutical Sciences

Pharmacokinetic ModelingBiochemistryMedicineRational Drug DesignAnalytical Chemistry +6

Effects of Omeprazole and Genetic Polymorphism of CYP2C19 on the Clopidogrel Active Metabolite

Xavier Boulenc, Nassim Djebli, Juan Shi, +4

Drug Metabolism and Disposition