NK cell CD16 surface expression and function is regulated by a disintegrin and metalloprotease-17 (ADAM17)

Rizwan Romee, Bree Foley, Todd Lenvik, +8

Blood

Neutrophil-neutrophil interactions under hydrodynamic shear stress involve L-selectin and PSGL-1. A mechanism that amplifies initial leukocyte accumulation of P-selectin in vitro.

Bruce Walcheck, Kirsty Moore, Rodger P. McEver, +1

Journal of Clinical Investigation

Endothelial CellsCell AdhesionImmunologyBlood CellHydrodynamic Shear Stress +16

Neutrophil rolling altered by inhibition of L-selectin shedding in vitro

Bruce Walcheck, Julius Kahn, Joseph M. Fisher, +8

Nature

InflammationGranulocyteImmunologyHematologyAutoimmunity +3

Pluripotent stem cell–derived NK cells with high-affinity noncleavable CD16a mediate improved antitumor activity

Zhu Huang, Robert Blum, Ryan Bjordahl, +11

Blood

Cell TherapyAntitumor ActivityImmunologyNk CellsImmunologic Mechanism +16

Targeting Natural Killer Cells to Acute Myeloid Leukemia<i>In Vitro</i>with a CD16 × 33 Bispecific Killer Cell Engager and ADAM17 Inhibition

Andres Wiernik, Bree Foley, Bin Zhang, +9

Clinical Cancer Research

Functional Interactions between Tumor and Peripheral Nerve: Morphology, Algogen Identification, and Behavioral Characterization of a New Murine Model of Cancer Pain

Paul W. Wacnik, Laura Eikmeier, Timothy Ruggles, +4

Journal of Neuroscience

Tissue EngineeringTumor InnervationPain MedicineMolecular PainBiomedical Engineering +24

Calmodulin Regulates L-Selectin Adhesion Molecule Expression and Function through a Protease-Dependent Mechanism

Julius Kahn, Bruce Walcheck, G I Migaki, +2

Cell

Protein SecretionProtein FunctionMolecular PhysiologySignal TransductionMolecular Regulation +8

A Genetically Engineered Primary Human Natural Killer Cell Platform for Cancer Immunotherapy

Emily J. Pomeroy, John Hunzeker, Mitchell G. Kluesner, +13

Molecular Therapy

Cancer ImmunosurveillanceImmunologyTherapeutic VaccineImmune Checkpoint InhibitorImmune Cell Therapy +6

Role of ADAM17 in the ectodomain shedding of TNF-α and its receptors by neutrophils and macrophages

Jessica H Bell, Amy Herrera, Ying Li, +1

Journal of Leukocyte Biology

Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy

Karrune Woan, Hansol Kim, Ryan Bjordahl, +28

Cell stem cell

Cell TherapyAdaptive Nk CellsAdaptive Immune SystemImmunologyAutoimmunity +7