TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection

Glen M. Chew, Tsuyoshi Fujita, Gabriela M. Webb, +18

PLoS Pathogens

Disease ProgressionAdaptive Immune SystemT-regulatory CellImmunologyImmune Restoration +17

T Cell Ig and Mucin Domain–Containing Protein 3 Is Recruited to the Immune Synapse, Disrupts Stable Synapse Formation, and Associates with Receptor Phosphatases

Kiera Clayton, Matthew Haaland, Matthew Douglas-Vail, +4

The Journal of Immunology

Soluble T Cell Immunoglobulin Mucin Domain 3 Is Shed from CD8 ⁺ T Cells by the Sheddase ADAM10, Is Increased in Plasma during Untreated HIV Infection, and Correlates with HIV Disease Progression

Kiera Clayton, Matthew Douglas-Vail, A. K. M. Nur-ur Rahman, +9

Journal of Virology

Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation

Mohamed Abdel‐Mohsen, Leonard Chávez, Ravi Tandon, +15

PLoS Pathogens

ImmunologyLatency Reversal AgentHiv TranscriptionImmunotherapyHiv Latency +15

Treatment intensification with maraviroc (CCR5 antagonist) leads to declines in CD16-expressing monocytes in cART-suppressed chronic HIV-infected subjects and is associated with improvements in neurocognitive test performance: implications for HIV-associated neurocognitive disease (HAND)

Lishomwa C. Ndhlovu, Tracie M Umaki, Glen M. Chew, +10

Journal of NeuroVirology

NeuropsychologyCd16-expressing MonocytesCognitive PerformanceTreatment And PreventionNeurovirology +11

Galectin-9 Is Rapidly Released During Acute HIV-1 Infection and Remains Sustained at High Levels Despite Viral Suppression Even in Elite Controllers

Ravi Tandon, Glen M. Chew, Mary Margaret Byron, +9

AIDS Research and Human Retroviruses

Elite ControllersChronic Hiv InfectionImmunodeficienciesAcute Hiv InfectionImmunology +23

Galectin-9 plasma levels reflect adverse hematological and immunological features in acute dengue virus infection

Haorile Chagan‐Yasutan, Lishomwa C. Ndhlovu, Talitha Lea Lacuesta, +11

Journal of Clinical Virology

HTLV-1 Tax Specific CD8+ T Cells Express Low Levels of Tim-3 in HTLV-1 Infection: Implications for Progression to Neurological Complications

Lishomwa C. Ndhlovu, Fábio E. Leal, Aaron M. Hasenkrug, +15

PLoS neglected tropical diseases

Adaptive Immune SystemImmunodeficienciesT-regulatory CellImmunologyPathology +19

Short Communication: Metformin Reduces CD4 T Cell Exhaustion in HIV-Infected Adults on Suppressive Antiretroviral Therapy

Cecilia M. Shikuma, Glen M. Chew, Lindsay B. Kohorn, +8

AIDS Research and Human Retroviruses

Expansion of Dysfunctional Tim-3–Expressing Effector Memory CD8+ T Cells during Simian Immunodeficiency Virus Infection in Rhesus Macaques

Tsuyoshi Fujita, Benjamin J. Burwitz, Glen M. Chew, +11

The Journal of Immunology