Finn P. Holding

Serine is a natural ligand and allosteric activator of pyruvate kinase M2

Barbara Chaneton, Petra Hillmann, Liang Zheng et al. · Nature · 2012 · 647 citations · Full text

Pyruvate Kinase M2, Natural Ligand, Signal Transduction +10

Crystal structure of human CDK4 in complex with a D-type cyclin

Philip J. Day, Anne Cleasby, Ian J. Tickle et al. · Proceedings of the National Academy of Sciences · 2009 · 225 citations · Full text

Structure of the Epigenetic Oncogene MMSET and Inhibition by <i>N</i>-Alkyl Sinefungin Derivatives

Dominic Tisi, Elisabetta Chiarparin, Emiliano Tamanini et al. · ACS Chemical Biology · 2016 · 66 citations

Structural Bioinformatics, Biomolecular Structure Prediction, Epigenetic Change +24

A prototype methodology combining surface‐enhanced laser desorption/ionization protein chip technology and artificial neural network algorithms to predict the chemoresponsiveness of breast cancer cell lines exposed to Paclitaxel and Doxorubicin under <b> <i>in vitro</i> </b> conditions

Graham Ball, Jo Hornbuckle, Finn P. Holding et al. · PROTEOMICS · 2003 · 63 citations

Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA₂) Discovered through X-ray Fragment Screening

Alison J.‐A. Woolford, Joseph E. Pero, Sridhar Aravapalli et al. · Journal of Medicinal Chemistry · 2016 · 23 citations · Full text

Proteinlipid Interaction, Elevated Levels, Cardiovascular Disease +11