Rapid, efficient, and simple motor neuron differentiation from human pluripotent stem cells

Daisuke Shimojo, Kazunari Onodera, Yukiko Doi-Torii, +11

Molecular Brain

Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis

Kotaro Oiwa, Seiji Watanabe, Kazunari Onodera, +7

Science Advances

Selective suppression of polyglutamine-expanded protein by lipid nanoparticle-delivered siRNA targeting CAG expansions in the mouse CNS

Tomoki Hirunagi, Kentaro Sahashi, Kiyoshi Tachikawa, +12

Molecular Therapy — Nucleic Acids

Unveiling synapse pathology in spinal bulbar muscular atrophy by genome-wide transcriptome analysis of purified motor neurons derived from disease specific iPSCs

Kazunari Onodera, Daisuke Shimojo, Y. Ishihara, +15

Molecular Brain

Src inhibition attenuates polyglutamine-mediated neuromuscular degeneration in spinal and bulbar muscular atrophy

Madoka Iida, Kentaro Sahashi, Naohide Kondo, +15

Nature Communications

Simple and efficient differentiation of human iPSCs into contractible skeletal muscles for muscular disease modeling

Muhammad Irfanur Rashid, Takuji Ito, Fuyuki Miya, +16

Scientific Reports

Genetic factors affecting survival in Japanese patients with sporadic amyotrophic lateral sclerosis: a genome-wide association study and verification in iPSC-derived motor neurons from patients

Ryoichi Nakamura, Genki Tohnai, Masahiro Nakatochi, +45

Journal of Neurology Neurosurgery & Psychiatry