Phase separation drives aberrant chromatin looping and cancer development

Jeong Hyun Ahn, Eric S. Davis, Timothy A. Daugird, +16

Nature

ChromatinChromatin RemodelingMedicineCell BiologyEpigenetics +2

Graft-versus-host disease disrupts intestinal microbial ecology by inhibiting Paneth cell production of α-defensins

Yoshihiro Eriguchi, Shuichiro Takashima, Hideyo Oka, +9

Blood

Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms

Linfeng Gao, Max Emperle, Yiran Guo, +17

Nature Communications

Breakthrough Trichosporonosis in Patients with Hematologic Malignancies Receiving Micafungin

Kosei Matsue, Hidetaka Uryu, Mihoko Koseki, +2

Clinical Infectious Diseases

A Phase Ib/II Study of Ivosidenib with Venetoclax ± Azacitidine in <i>IDH1</i> -Mutated Myeloid Malignancies

Curtis A. Lachowiez, Sanam Loghavi, Zhihong Zeng, +24

Blood Cancer Discovery

Synthetic retinoid Am80 ameliorates chronic graft-versus-host disease by down-regulating Th1 and Th17

Hisakazu Nishimori, Yoshinobu Maeda, Takanori Teshima, +10

Blood

Suppression of rat deoxycorticosterone-salt hypertension by kallikrein-kinin system.

Masataka Majima, Makoto Katori, Mitsuo Hanazuka, +7

Hypertension

HypertensionBlood PressureOxidative StressMolecular PharmacologyRenal Function +15

Successful Treatment of Breakthrough Trichosporon asahii Fungemia with Voriconazole in a Patient with Acute Myeloid Leukemia

Noboru Asada, Hidetaka Uryu, Mihoko Koseki, +3

Clinical Infectious Diseases

Hematological MalignancyBreakthrough TrichosporonSuccessful TreatmentVoriconazole TreatmentMedicine +8

Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic

Dongxu Li, Xufen Yu, Jithesh Kottur, +16

Oncogene

Anti-cancer TherapeuticIkaros Protac DegraderMedicineDrug DiscoveryImmune Checkpoint Inhibitor +7

α-Mannan induces Th17-mediated pulmonary graft-versus-host disease in mice

Hidetaka Uryu, Daigo Hashimoto, Koji Kato, +12

Blood