Mike Birch

F901318 represents a novel class of antifungal drug that inhibits dihydroorotate dehydrogenase

Jason D. Oliver, Graham E. M. Sibley, Nicola Beckmann et al. · Proceedings of the National Academy of Sciences · 2016 · 269 citations · Full text

Dihydroorotate Dehydrogenase, Bioorganic Chemistry, Pyrimidine Biosynthesis +18

Effect of the Novel Antifungal Drug F901318 (Olorofim) on Growth and Viability of Aspergillus fumigatus

Saskia du Pré, Nicola Beckmann, Mariana Cruz Almeida et al. · Antimicrobial Agents and Chemotherapy · 2018 · 105 citations · Full text

In vitro activity of the novel antifungal compound F901318 against difficult-to-treat Aspergillus isolates

Jochem B. Buil, Antonius J. M. M. Rijs, Jacques F. Meis et al. · Journal of Antimicrobial Chemotherapy · 2017 · 102 citations · Full text

Evidence of multiple extracellular phospholipase activities of Aspergillus fumigatus

Mike Birch, G. D. Robson, D. Law et al. · Infection and Immunity · 1996 · 88 citations · Full text

Aspergillus fumigatus strains that evolve resistance to the agrochemical fungicide ipflufenoquin in vitro are also resistant to olorofim

Norman van Rhijn, Isabelle S. R. Storer, Mike Birch et al. · Nature Microbiology · 2023 · 55 citations · Full text