Peptidoglycan Recognition Protein Tag7 Forms a Cytotoxic Complex with Heat Shock Protein 70 in Solution and in Lymphocytes

Lidia P. Sashchenko, E. A. Dukhanina, Denis V. Yashin, +8

Journal of Biological Chemistry

Tag7 (PGLYRP1) in Complex with Hsp70 Induces Alternative Cytotoxic Processes in Tumor Cells via TNFR1 Receptor

Denis V. Yashin, Olga K. Ivanova, Natalia V. Soshnikova, +7

Journal of Biological Chemistry

Cytotoxic T lymphocytes carrying a pattern recognition protein Tag7 can detect evasive, HLA-negative but Hsp70-exposing tumor cells, thereby ensuring FasL/Fas-mediated contact killing

Lidia P. Sashchenko, E. A. Dukhanina, Yury V. Shatalov, +6

Blood

The Tag7–Hsp70 cytotoxic complex induces tumor cell necroptosis via permeabilisation of lysosomes and mitochondria

Denis V. Yashin, Elena A. Romanova, Olga K. Ivanova, +1

Biochimie

Mitochondrial FunctionApoptosisAutophagyImmunologyCell Death +5

Kinetic Parameters and Cytotoxic Activity of Recombinant Methionine γ-Lyase from Clostridium tetani, Clostridium sporogenes, Porphyromonas gingivalis and Citrobacter freundii

Elena A. Morozova, Vitalia V. Kulikova, Denis V. Yashin, +7

Acta Naturae

Hsp70 Interacts with the TREM-1 Receptor Expressed on Monocytes and Thereby Stimulates Generation of Cytotoxic Lymphocytes Active against MHC-Negative Tumor Cells

Tatiana N. Sharapova, Elena A. Romanova, Olga K. Ivanova, +2

International Journal of Molecular Sciences

Innate Immunity Protein Tag7 Induces 3 Distinct Populations of Cytotoxic Cells That Use Different Mechanisms to Exhibit Their Antitumor Activity on Human Leukocyte Antigen-Deficient Cancer Cells

Tatiana N. Sharapova, Olga K. Ivanova, Natalia Soshnikova, +3

Journal of Innate Immunity

Tag7 TreatmentInnate Immune SystemImmunologyNk CellsCell Death +17

Opposite roles of metastasin (S100A4) in two potentially tumoricidal mechanisms involving human lymphocyte protein Tag7 and Hsp70

E. A. Dukhanina, Tamara I. Lukyanova, Yury V. Shatalov, +5

Proceedings of the National Academy of Sciences

ImmunologyImmunoeditingCell DeathImmunologic MechanismExcess Mts1 +15

FasL on the surface of Tag7 (PGRP-S)-activated lymphocytes induces necroptosis in HLA-negative tumor cells with the involvement of lysosomes and mitochondria

Tatiana N. Sharapova, Elena A. Romanova, Lidia P. Sashchenko, +1

Biochimie

Hla-negative Tumor CellsLymphocytes InducesAutoimmune DiseaseApoptosisAutophagy +10

Protein PGLYRP1/Tag7 Peptides Decrease the Proinflammatory Response in Human Blood Cells and Mouse Model of Diffuse Alveolar Damage of Lung through Blockage of the TREM-1 and TNFR1 Receptors

Tatiana N. Sharapova, Elena A. Romanova, Alexey N. Minakov, +7

International Journal of Molecular Sciences

Acute Lung InjuryInflammatory Lung DiseaseLung InflammationInnate Immune SystemImmunology +19