Quercetin induces apoptosis and autophagy in primary effusion lymphoma cells by inhibiting PI3K/AKT/mTOR and STAT3 signaling pathways

Marisa Granato, Celeste Rizzello, Maria Saveria Gilardini Montani, +7

The Journal of Nutritional Biochemistry

Cell AutophagyMitophagyChemoprevention StrategyApoptosisAutophagy +8

Epstein-Barr Virus Blocks the Autophagic Flux and Appropriates the Autophagic Machinery To Enhance Viral Replication

Marisa Granato, Roberta Santarelli, Antonella Farina, +4

Journal of Virology

Characterization and Intracellular Localization of the Epstein-Barr Virus Protein BFLF2: Interactions with BFRF1 and with the Nuclear Lamina

Roberta Gonnella, Antonella Farina, Roberta Santarelli, +10

Journal of Virology

Nuclear LaminaImmunologyViral PathogenesisPathologyEbv Mutant +16

EBV reduces autophagy, intracellular ROS and mitochondria to impair monocyte survival and differentiation

Maria Saveria Gilardini Montani, Roberta Santarelli, Marisa Granato, +4

Autophagy

Histone deacetylase inhibitors VPA and TSA induce apoptosis and autophagy in pancreatic cancer cells

Maria Saveria Gilardini Montani, Marisa Granato, Claudio Santoni, +5

Cellular Oncology

Cancer ResearchMitophagyCell AutophagyPancreatic CancerMedicine +11

HSP70 inhibition by 2-phenylethynesulfonamide induces lysosomal cathepsin D release and immunogenic cell death in primary effusion lymphoma

Marisa Granato, Valentina Lacconi, Marina Peddis, +9

Cell Death and Disease

Deletion of Epstein-Barr Virus BFLF2 Leads to Impaired Viral DNA Packaging and Primary Egress as Well as to the Production of Defective Viral Particles

Marisa Granato, Regina Feederle, Antonella Farina, +5

Journal of Virology

Viral ReplicationImmunologyMolecular BiologyPathologyViral Structural Protein +16

STAT3 activation by KSHV correlates with IL-10, IL-6 and IL-23 release and an autophagic block in dendritic cells

Roberta Santarelli, Roberta Gonnella, Giulia Di Giovenale, +6

Scientific Reports

Immune RegulationImmunologyPathologyImmunologic MechanismImmunotherapy +16

Apigenin, by activating p53 and inhibiting STAT3, modulates the balance between pro-apoptotic and pro-survival pathways to induce PEL cell death

Marisa Granato, Maria Saveria Gilardini Montani, Roberta Santarelli, +3

Journal of Experimental & Clinical Cancer Research

Mutant p53, Stabilized by Its Interplay with HSP90, Activates a Positive Feed-Back Loop Between NRF2 and p62 that Induces Chemo-Resistance to Apigenin in Pancreatic Cancer Cells

Maria Saveria Gilardini Montani, Nives Cecere, Marisa Granato, +6

Cancers

Mutant P53Tumor BiologyPancreatic CancerOncogenic AgentMedicine +13