Paul E. Sladen

CRISPR-Cas9 correction of OPA1 c.1334G>A: p.R445H restores mitochondrial homeostasis in dominant optic atrophy patient-derived iPSCs

Paul E. Sladen, Pedro R.L. Perdigão, Grace Salsbury et al. · Molecular Therapy — Nucleic Acids · 2021 · 45 citations · Full text

HIF1α is necessary for exercise-induced neuroprotection while HIF2α is needed for dopaminergic neuron survival in the substantia nigra pars compacta

Michelle Smeyne, Paul E. Sladen, Yun Jiao et al. · Neuroscience · 2015 · 27 citations · Full text

Eupatilin Improves Cilia Defects in Human CEP290 Ciliopathy Models

Julio C. Corral-Serrano, Paul E. Sladen, Olivia F. Rezek et al. · Cells · 2023 · 23 citations · Full text

Modelling autosomal dominant optic atrophy associated with <i>OPA1</i> variants in iPSC-derived retinal ganglion cells

Paul E. Sladen, Katarina Jovanović, Rosellina Guarascio et al. · Human Molecular Genetics · 2022 · 21 citations · Full text

AAV-RPGR Gene Therapy Rescues Opsin Mislocalisation in a Human Retinal Organoid Model of RPGR-Associated X-Linked Retinitis Pigmentosa

Paul E. Sladen, Arifa Naeem, Toyin Adefila-Ideozu et al. · International Journal of Molecular Sciences · 2024 · 18 citations · Full text