Guilian Xu

Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase

Joanna L. Jankowsky, Daniel J. Fadale, Jeffrey C. Anderson et al. · Human Molecular Genetics · 2003 · 1.6K citations · Full text

BACE1, a Major Determinant of Selective Vulnerability of the Brain to Amyloid-β Amyloidogenesis, is Essential for Cognitive, Emotional, and Synaptic Functions

Fiona M. Laird, Huaibin Cai, Alena Savonenko et al. · Journal of Neuroscience · 2005 · 518 citations · Full text

Environmental Enrichment Mitigates Cognitive Deficits in a Mouse Model of Alzheimer's Disease

Joanna L. Jankowsky, Tatiana Melnikova, Daniel J. Fadale et al. · Journal of Neuroscience · 2005 · 514 citations · Full text

Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: Relationships to β-amyloid deposition and neurotransmitter abnormalities

Alena Savonenko, Guilian Xu, Tatiana Melnikova et al. · Neurobiology of Disease · 2005 · 390 citations · Full text

Neurodegenerative Diseases, Episodic-like Memory Deficits, Alzheimer's Disease +10

Environmental Enrichment Exacerbates Amyloid Plaque Formation in a Transgenic Mouse Model of Alzheimer Disease

Joanna L. Jankowsky, Guilian Xu, David Fromholt et al. · Journal of Neuropathology & Experimental Neurology · 2003 · 255 citations · Full text