Darren J. Mitchell

1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain

Emmanuel H. Demont, Paul Bamborough, Chun‐wa Chung et al. · ACS Medicinal Chemistry Letters · 2014 · 91 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +14

Structure-Based Optimization of Naphthyridones into Potent ATAD2 Bromodomain Inhibitors

Paul Bamborough, Chun‐wa Chung, Rebecca C. Furze et al. · Journal of Medicinal Chemistry · 2015 · 83 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Fragment-Based Discovery of Low-Micromolar ATAD2 Bromodomain Inhibitors

Emmanuel H. Demont, Chun‐wa Chung, Rebecca C. Furze et al. · Journal of Medicinal Chemistry · 2015 · 79 citations · Full text

Pharmacy, Molecular Biology, Oncology +16

A Chemical Probe for the ATAD2 Bromodomain

Paul Bamborough, Chun‐wa Chung, Emmanuel H. Demont et al. · Angewandte Chemie International Edition · 2016 · 75 citations · Full text

Pharmacy, Medicinal Chemistry, Molecular Biology +17

Discovery of a Bromodomain and Extraterminal Inhibitor with a Low Predicted Human Dose through Synergistic Use of Encoded Library Technology and Fragment Screening

Christopher R. Wellaway, Dominique Amans, Paul Bamborough et al. · Journal of Medicinal Chemistry · 2020 · 71 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14