HIV-1 Vpr-Mediated G2 Arrest Involves the DDB1-CUL4AVPRBP E3 Ubiquitin Ligase

Jean-Philippe Belzile, Ghislaine Duisit, Nicole Rougeau, +3

PLoS Pathogens

Viral ReplicationG2 ArrestViral PersistenceVprbp KnockdownNeurovirology +13

Mutagenic analysis of human immunodeficiency virus type 1 Vpr: role of a predicted N-terminal alpha-helical structure in Vpr nuclear localization and virion incorporation

Xiaojian Yao, Ramu A. Subbramanian, Nicole Rougeau, +3

Journal of Virology

Viral ReplicationEngineeringMolecular BiologyVirus StructureVpr Nuclear Localization +16

Vpr Stimulates Viral Expression and Induces Cell Killing in Human Immunodeficiency Virus Type 1-Infected Dividing Jurkat T Cells

Xiaojian Yao, Andrew J. Mouland, Ramu A. Subbramanian, +4

Journal of Virology

Human Immunodeficiency Virus Type 1 (HIV-1) Vpr Functions as an Immediate-Early Protein during HIV-1 Infection

Mohammed Hrimech, Xiaojian Yao, François Bachand, +2

Journal of Virology

Incorporation of Vpr into Human Immunodeficiency Virus Type 1 Requires a Direct Interaction with the p6 Domain of the p55 Gag Precursor

François Bachand, Mohammed Hrimech, Nicole Rougeau, +1

Journal of Biological Chemistry

The Putative Alpha Helix 2 of Human Immunodeficiency Virus Type 1 Vpr Contains a Determinant Which Is Responsible for the Nuclear Translocation of Proviral DNA in Growth-Arrested Cells

Zilin Nie, Dominique Bergeron, Ramu A. Subbramanian, +4

Journal of Virology

Formation of Mobile Chromatin-Associated Nuclear Foci Containing HIV-1 Vpr and VPRBP Is Critical for the Induction of G2 Cell Cycle Arrest

Jean-Philippe Belzile, Levon Abrahamyan, Francine C. A. Gérard, +2

PLoS Pathogens

Human immunodeficiency virus type 1 Vpr localization: nuclear transport of a viral protein modulated by a putative amphipathic helical structure and its relevance to biological activity

Ramu A. Subbramanian, Xiaojian Yao, Hugo Dilhuydy, +4

Journal of Molecular Biology

Biological ActivityVirus StructureViral ReplicationVpr LocalizationProtein Folding +10

HIV-1 Vpr Induces the K48-Linked Polyubiquitination and Proteasomal Degradation of Target Cellular Proteins To Activate ATR and Promote G ₂ Arrest

Jean-Philippe Belzile, Jonathan Richard, Nicole Rougeau, +2

Journal of Virology

Cell-surface processing of extracellular human immunodeficiency virus type 1 Vpr by proprotein convertases

Yong Xiao, Gang Chen, Jonathan Richard, +4

Virology

Viral ReplicationMedicineNatural SciencesHuman RetrovirusMolecular Biology +7