Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites

François Gerbe, Emmanuelle Sidot, Danielle J. Smyth, +13

Nature

Parasitic DiseaseMucosal ImmunologyHelminthologyPathogenesisImmunology +5

Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium

François Gerbe, Johan H. van Es, Leila Makrini, +9

The Journal of Cell Biology

Cell PhysiologyDevelopmental BiologySignal TransductionTumor MicroenvironmentDistinct Atoh1 +13

Cell-Cycle Regulation Accounts for Variability in Ki-67 Expression Levels

Michal Sobecki, Karim Mrouj, Jacques Colinge, +5

Cancer Research

The cell proliferation antigen Ki-67 organises heterochromatin

Michal Sobecki, Karim Mrouj, Alain Camasses, +18

eLife

Cell ProliferationCell CycleEpigeneticsTumor BiologyTranscriptional Regulation +17

Single-cell mapping of the thymic stroma identifies IL-25-producing tuft epithelial cells

Chamutal Bornstein, Shir Nevo, Amir Giladi, +14

Nature

Autoimmune DiseaseLymphocyte DevelopmentMedicineImmune RegulationImmunology +6

Primitive Endoderm Differentiates via a Three-Step Mechanism Involving Nanog and RTK Signaling

Stephen Frankenberg, François Gerbe, Sylvain Bessonnard, +4

Developmental Cell

Primitive Endoderm DifferentiatesSignal TransductionDevelopmental BiologySignaling PathwayMedicine +10

Dynamic expression of Lrp2 pathway members reveals progressive epithelial differentiation of primitive endoderm in mouse blastocyst

François Gerbe, Brian Cox, Janet Rossant, +1

Developmental Biology

Lineage PlasticityCell LineageDevelopmental BiologyPrimitive EndodermBlastema +10

Intestinal epithelial tuft cell induction is negated by a murine helminth and its secreted products

Claire Drurey, Håvard T. Lindholm, Gillian Coakley, +8

The Journal of Experimental Medicine

ImmunologyGastroenterologyImmune RegulationSecreted ProductsInnate Immunity +16

Tuft cell acetylcholine is released into the gut lumen to promote anti-helminth immunity

Marième Ndjim, Imène Gasmi, Fabien Herbert, +23

Immunity

The IL-25-dependent tuft cell circuit driven by intestinal helminths requires macrophage migration inhibitory factor (MIF)

Fumi Varyani, Stephan Löser, Kara J. Filbey, +9

Mucosal Immunology