Dual Inhibitors of Amyloid-β and Tau Aggregation with Amyloid-β Disaggregating Properties: Extended <i>In Cellulo</i>, <i>In Silico</i>, and Kinetic Studies of Multifunctional Anti-Alzheimer’s Agents

Anna Pasieka, Dawid Panek, Natalia Szałaj, +5

ACS Chemical Neuroscience

1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer’s disease

Tomasz Wichur, Anna Więckowska, Krzysztof Więckowski, +9

European Journal of Medicinal Chemistry

Medicinal ChemistryAlzheimer's DiseaseBiochemistry1-Benzylpyrrolidine-3-amine-based Buche InhibitorsMedicine +9

Design, Synthesis, and Biological Evaluation of 1-Benzylamino-2-hydroxyalkyl Derivatives as New Potential Disease-Modifying Multifunctional Anti-Alzheimer’s Agents

Dawid Panek, Anna Więckowska, Jakub Jończyk, +13

ACS Chemical Neuroscience

Design, Synthesis, and Biological Evaluation of 2-(Benzylamino-2-Hydroxyalkyl)Isoindoline-1,3-Diones Derivatives as Potential Disease-Modifying Multifunctional Anti-Alzheimer Agents

Dawid Panek, Anna Więckowska, Anna Pasieka, +6

Molecules

Synthesis, Molecular Modelling and Biological Evaluation of Novel Heterodimeric, Multiple Ligands Targeting Cholinesterases and Amyloid Beta

Michalina Hebda, Marek Bajda, Anna Więckowska, +8

Molecules

Combinatorial ChemistryNovel HeterodimericPeptide ScienceAmyloid Beta AggregationNeurochemical Biomarkers +20

Superoxide dismutase and taurine supplementation improves in vitro blastocyst yield from poor-quality feline oocytes

Małgorzata Ochota, Anna Pasieka, Wojciech Niżański

Theriogenology

OocyteTheriogenologyDevelopmental BiologyFertilityPhysiology +11

Discovery of 1-(phenylsulfonyl)-1H-indole-based multifunctional ligands targeting cholinesterases and 5-HT6 receptor with anti-aggregation properties against amyloid-beta and tau

Tomasz Wichur, Anna Pasieka, Justyna Godyń, +14

European Journal of Medicinal Chemistry

Discovery of multifunctional anti-Alzheimer’s agents with a unique mechanism of action including inhibition of the enzyme butyrylcholinesterase and γ-aminobutyric acid transporters

Anna Pasieka, Dawid Panek, Jakub Jończyk, +17

European Journal of Medicinal Chemistry

Neurodegenerative DiseasesAlzheimer's DiseaseBiochemistryMedicinePharmacological Agent +9

Multidirectional <i>in vitro</i> and <i>in cellulo</i> studies as a tool for identification of multi-target-directed ligands aiming at symptoms and causes of Alzheimer’s disease

Natalia Szałaj, Justyna Godyń, Jakub Jończyk, +10

Journal of Enzyme Inhibition and Medicinal Chemistry

Discovery of new, highly potent and selective inhibitors of BuChE - design, synthesis, in vitro and in vivo evaluation and crystallography studies

Dawid Panek, Anna Pasieka, Gniewomir Latacz, +14

European Journal of Medicinal Chemistry

Combinatorial ChemistryMedicinal ChemistryBiochemistryCrystallography StudiesVivo Evaluation +8