Mark Hedglin

Design and evaluation of ‘Linkerless’ hydroxamic acids as selective HDAC8 inhibitors

Keris KrennHrubec, Brett Marshall, Mark Hedglin et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 194 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Biochemistry +11

Human Alkyladenine DNA Glycosylase Employs a Processive Search for DNA Damage

Mark Hedglin, Patrick O’Brien · Biochemistry · 2008 · 73 citations · Full text

Chromatin, Genome Instability, Nucleic Acid Chemistry +11

Hopping Enables a DNA Repair Glycosylase To Search Both Strands and Bypass a Bound Protein

Mark Hedglin, Patrick O’Brien · ACS Chemical Biology · 2010 · 71 citations

Bound Protein, Dna Damage, Spontaneous Dna Damage +18

Stability of the human polymerase δ holoenzyme and its implications in lagging strand DNA synthesis

Mark Hedglin, Binod Pandey, Stephen J. Benkovic · Proceedings of the National Academy of Sciences · 2016 · 65 citations · Full text

Chromatin, Genome Instability, Nucleic Acid Chemistry +14

Structure of the human clamp loader reveals an autoinhibited conformation of a substrate-bound AAA+ switch

Christl Gaubitz, Xingchen Liu, Nicholas P. Stone et al. · Proceedings of the National Academy of Sciences · 2020 · 60 citations · Full text

Protein Assembly, Molecular Biology, Analytical Ultracentrifugation +16