Judi O’Shaughnessy

RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS

Holly Spence, Fergal M. Waldron, Rebecca S. Saleeb et al. · Acta Neuropathologica · 2024 · 49 citations · Full text

Life Sciences, Neurology, Neuroscience +17

<scp>NLRP3</scp> inflammasome as a key molecular target underlying cognitive resilience in amyotrophic lateral sclerosis

Poulomi Banerjee, Elizabeth Elliott, Olivia M. Rifai et al. · The Journal of Pathology · 2021 · 30 citations · Full text

Life Sciences, Neurology, Neuroscience +17

<scp>pTDP</scp>‐43 aggregates accumulate in non‐central nervous system tissues prior to symptom onset in amyotrophic lateral sclerosis: a case series linking archival surgical biopsies with clinical phenotypic data

Samuel Pattle, Judi O’Shaughnessy, Owen Kantelberg et al. · The Journal of Pathology Clinical Research · 2022 · 26 citations · Full text

Medicine, Neurology, Pathology +17

Random forest modelling demonstrates microglial and protein misfolding features to be key phenotypic markers in <scp> <i>C9orf72</i> ‐ALS </scp>

Olivia M. Rifai, James Longden, Judi O’Shaughnessy et al. · The Journal of Pathology · 2022 · 21 citations · Full text

Medicine, Neurology, Neuroscience +17

Two-color coincidence single-molecule pulldown for the specific detection of disease-associated protein aggregates

Rebecca S. Saleeb, Craig Leighton, Ji‐Eun Lee et al. · Science Advances · 2023 · 19 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17