Nicholas J. Slipek

Highly efficient multiplex human T cell engineering without double-strand breaks using Cas9 base editors

Beau R. Webber, Cara-lin Lonetree, Mitchell G. Kluesner et al. · Nature Communications · 2019 · 227 citations · Full text

Life Sciences, Biotechnology, Molecular Biology +17

CRISPR-Cas9 cytidine and adenosine base editing of splice-sites mediates highly-efficient disruption of proteins in primary and immortalized cells

Mitchell G. Kluesner, Walker S. Lahr, Cara-lin Lonetree et al. · Nature Communications · 2021 · 116 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Dose-dependent differential mRNA target selection and regulation by let-7a-7f and miR-17-92 cluster microRNAs

Jingmin Shu, Zhilian Xia, Lihua Li et al. · RNA Biology · 2012 · 81 citations · Full text

Life Sciences, Genetics, Molecular Biology +14

Targeting the intracellular immune checkpoint CISH with CRISPR-Cas9-edited T cells in patients with metastatic colorectal cancer: a first-in-human, single-centre, phase 1 trial

Emil Lou, Modassir S Choudhry, Timothy K. Starr et al. · The Lancet Oncology · 2025 · 51 citations

Medicine, Immunology, Oncology +16

Highly efficient multiplex human T cell engineering without double-strand breaks using Cas9 base editors

Beau R. Webber, Cara-lin Lonetree, Mitchell G. Kluesner et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2018 · 35 citations · Full text

Life Sciences, Biotechnology, Molecular Biology +17