Extracellular Superoxide Dismutase Overexpression Can Reverse the Course of Hypoxia-Induced Pulmonary Hypertension

Mohamed N. Ahmed, Yinzhong Zhang, Champa N. Codipilly, +4

Molecular Medicine

20-HETE-induced mitochondrial superoxide production and inflammatory phenotype in vascular smooth muscle is prevented by glucose-6-phosphate dehydrogenase inhibition

Anand Lakhkar, Vidhi Dhagia, Sachindra Raj Joshi, +6

American Journal of Physiology-Heart and Circulatory Physiology

Dehydroepiandrosterone promotes pulmonary artery relaxation by NADPH oxidation-elicited subunit dimerization of protein kinase G 1α

Dhara Patel, Sharath Kandhi, Melissa R. Kelly, +2

American Journal of Physiology-Lung Cellular and Molecular Physiology

Pulmonary HypertensionRedox BiologyOxidative StressMolecular PharmacologyPulmonary Pharmacology +19

Roles for cytosolic NADPH redox in regulating pulmonary artery relaxation by thiol oxidation-elicited subunit dimerization of protein kinase G1α

Boon Hwa Neo, Dhara Patel, Sharath Kandhi, +1

American Journal of Physiology-Heart and Circulatory Physiology

Pkg DimerizationRedox BiologyCellular PhysiologyOxidative StressMolecular Pharmacology +26

Potential role of mitochondrial superoxide decreasing ferrochelatase and heme in coronary artery soluble guanylate cyclase depletion by angiotensin II

Dhara Patel, Raed Alhawaj, Melissa R. Kelly, +5

American Journal of Physiology-Heart and Circulatory Physiology

Cardiovascular PharmacologyAng IiRedox BiologyOxidative StressPotential Role +18

Glutamine Supplementation Alleviates Vasculopathy and Corrects Metabolic Profile in an In Vivo Model of Endothelial Cell Dysfunction

Francesco Addabbo, Qiuying Chen, Dhara Patel, +7

PLoS ONE

Lipid PeroxidationRenal InflammationOxidative StressInflammationMetabolic Syndrome +17

Rotenone-stimulated superoxide release from mitochondrial complex I acutely augments L-type Ca²⁺ current in A7r5 aortic smooth muscle cells

Rikuo Ochi, Vidhi Dhagia, Anand Lakhkar, +3

American Journal of Physiology-Heart and Circulatory Physiology

Heme biosynthesis modulation via δ-aminolevulinic acid administration attenuates chronic hypoxia-induced pulmonary hypertension

Raed Alhawaj, Dhara Patel, Melissa R. Kelly, +2

American Journal of Physiology-Lung Cellular and Molecular Physiology

Acute Lung InjuryHypertensionLung InflammationPulmonary HypertensionBpa Protoporphyrin Ix +21

Violet/blue light activates Nrf2 signaling and modulates the inflammatory response of THP-1 monocytes

Linda Trotter, Dhara Patel, Samuel Dubin, +6

Photochemical & Photobiological Sciences

InflammationCytokineLight RegulationPhotoreceptor CellSignal Transduction +8

Exposure of mice to chronic hypoxia attenuates pulmonary arterial contractile responses to acute hypoxia by increases in extracellular hydrogen peroxide

Dhara Patel, Raed Alhawaj, Michael S. Wolin

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Acute Lung InjuryInflammatory Lung DiseaseLung InflammationRedox BiologyOxidative Stress +18