Reduced H3K27me3 and DNA Hypomethylation Are Major Drivers of Gene Expression in K27M Mutant Pediatric High-Grade Gliomas

Sebastian Bender, Yujie Tang, Anders M. Lindroth, +38

Cancer Cell

Neuro-oncologyRadiation OncologyPediatric Brain TumorsCancer Cell BiologyCancer Genomics +7

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

David Jones, Barbara Hutter, Natalie Jäger, +70

Nature Genetics

Neuro-oncologyMolecular NeuroscienceGliomaPathologyMolecular Pathology +5

Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling

Marc Zuckermann, Volker Hovestadt, Christiane B. Knobbe‐Thomsen, +15

Nature Communications

Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme

Weijun Feng, Daisuke Kawauchi, Huiqin Körkel-Qu, +23

Nature Communications

Targeting Self-Renewal in High-Grade Brain Tumors Leads to Loss of Brain Tumor Stem Cells and Prolonged Survival

Zhe Zhu, Muhammad Amir Khan, Markus Weiler, +14

Cell stem cell

Neuro-oncologyMedicineAdult Stem CellProlonged SurvivalStem-cell Therapy +9

The Senescence-associated Secretory Phenotype Mediates Oncogene-induced Senescence in Pediatric Pilocytic Astrocytoma

Juliane L. Buhl, Florian Selt, Thomas Hielscher, +28

Clinical Cancer Research

An activated mutant BRAF kinase domain is sufficient to induce pilocytic astrocytoma in mice

Jan Gronych, Andrey Korshunov, Josephine Bageritz, +13

Journal of Clinical Investigation

Neuro-oncologyOncogenic Braf ActivationSystems BiologySignal TransductionSignaling Pathway +13

Novel MYC-driven medulloblastoma models from multiple embryonic cerebellar cells

Daisuke Kawauchi, Robert J. Ogg, Liang-Tseng Liu, +17

Oncogene

Establishment and application of a novel patient-derived KIAA1549:BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing

Florian Selt, Juliane Hohloch, Thomas Hielscher, +21

Oncotarget

Pediatric Brain TumorsImmunologyPreclinical DrugGliomaTumor Biology +17

Downregulation of PRDX1 by promoter hypermethylation is frequent in 1p/19q-deleted oligodendroglial tumours and increases radio- and chemosensitivity of Hs683 glioma cells in vitro

L M Dittmann, Andreas Danner, Jan Gronych, +13

Oncogene

Hs683 Glioma CellsCell RegulationGliomaMedicinePromoter Hypermethylation +9