Synchronized Whole Cell Oscillations in Mitochondrial Metabolism Triggered by a Local Release of Reactive Oxygen Species in Cardiac Myocytes

Miguel A. Aon, Sonia Cortassa, Eduardo Marbán, +1

Journal of Biological Chemistry

Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice

Sarah J. Mitchell, Julio Madrigal‐Matute, Morten Scheibye‐Knudsen, +44

Cell Metabolism

AgingLongevityPhysiologyEndocrinologyNeuroscience +5

An Integrated Model of Cardiac Mitochondrial Energy Metabolism and Calcium Dynamics

Sonia Cortassa, Miguel A. Aon, Eduardo Marbán, +2

Biophysical Journal

MechanobiologyCardiac MuscleBiochemistryMitochondrial FunctionBioenergetics +12

Redox-optimized ROS balance: A unifying hypothesis

Miguel A. Aon, Sonia Cortassa, Brian O’Rourke

Biochimica et Biophysica Acta (BBA) - Bioenergetics

Chemical KineticsChemical EngineeringEngineeringMedicineRedox-optimized Ros Balance +6

Reversal of Mitochondrial Transhydrogenase Causes Oxidative Stress in Heart Failure

Alexander Nickel, Albrecht von Hardenberg, Mathias Hohl, +26

Cell Metabolism

Reductive StressHeart FailureBiochemistryMitochondrial FunctionPhysiology +5

Elevated Cytosolic Na ⁺ Decreases Mitochondrial Ca ²⁺ Uptake During Excitation-Contraction Coupling and Impairs Energetic Adaptation in Cardiac Myocytes

Christoph Maack, Sonia Cortassa, Miguel A. Aon, +3

Circulation Research

Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice

Sarah J. Mitchell, Michel Bernier, Miguel A. Aon, +20

Cell Metabolism

Lifespan ExtensionLongevityMedicinePhysiologyNicotine +4

A Mitochondrial Oscillator Dependent on Reactive Oxygen Species

Sonia Cortassa, Miguel A. Aon, Raimond L. Winslow, +1

Biophysical Journal

BiologyMitochondrial Oscillator DependentMitochondrial FunctionPhysiologyMetabolism +3

Percolation and criticality in a mitochondrial network

Miguel A. Aon, Sonia Cortassa, Brian O’Rourke

Proceedings of the National Academy of Sciences

Network AnalysisCytoskeletonMitochondrial NetworkRedox BiologyCellular Physiology +18

A Computational Model Integrating Electrophysiology, Contraction, and Mitochondrial Bioenergetics in the Ventricular Myocyte

Sonia Cortassa, Miguel A. Aon, Brian O’Rourke, +4

Biophysical Journal

MechanobiologyVentricular MyocyteCardiac MuscleEngineeringNeurophysiology +10