Lyle W. Ostrow

The C9orf72 repeat expansion disrupts nucleocytoplasmic transport

Ke Zhang, Christopher J. Donnelly, Aaron R. Haeusler et al. · Nature · 2015 · 974 citations

Natural Sciences, Molecular Biology, Dna Replication +6

RAN proteins and RNA foci from antisense transcripts in <i>C9ORF72</i> ALS and frontotemporal dementia

Tao Zu, Yuanjing Liu, Mónica Báñez-Coronel et al. · Proceedings of the National Academy of Sciences · 2013 · 772 citations · Full text

Genetics, Antisense Transcripts, Disease Gene Identification +19

An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: a phase 1, randomised, first-in-man study

Timothy M. Miller, Alan Pestronk, William David et al. · The Lancet Neurology · 2013 · 603 citations · Full text

Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis

Shin Hyeok Kang, Ying Li, Masahiro Fukaya et al. · Nature Neuroscience · 2013 · 568 citations · Full text

Gray Matter Oligodendrocytes, Neurodegenerative Diseases, Neuroregeneration +10

Human endogenous retrovirus-K contributes to motor neuron disease

Wenxue Li, Myoung-Hwa Lee, Lisa Henderson et al. · Science Translational Medicine · 2015 · 471 citations · Full text