Dual mRNA co-delivery for in situ generation of phagocytosis-enhanced CAR macrophages augments hepatocellular carcinoma immunotherapy

Zhenmei Yang, Ying Liu, Kun Zhao, +14

Journal of Controlled Release

Situ GenerationCancer ImmunosurveillanceImmunologyDual Mrna Co-deliveryCancer Vaccines +6

mRNA-Laden Lipid-Nanoparticle-Enabled <i>in Situ</i> CAR-Macrophage Engineering for the Eradication of Multidrug-Resistant Bacteria in a Sepsis Mouse Model

Chunwei Tang, Weiqiang Jing, Kun Han, +23

ACS Nano

Cell membrane derived liposomes loaded with DNase I target neutrophil extracellular traps which inhibits colorectal cancer liver metastases

Zhaozhong Wang, Chen Chen, Chongdeng Shi, +11

Journal of Controlled Release

Neutrophil Extracellular TrapsCell MembraneExtracellular MicrovesiclesTumor TargetingCell Biology +3

Inhaled mRNA Nanoformulation with Biogenic Ribosomal Protein Reverses Established Pulmonary Fibrosis in a Bleomycin‐Induced Murine Model

Rui Zhang, Weiqiang Jing, Chen Chen, +24

Advanced Materials

EngineeringInflammatory Lung DiseaseLung InflammationMolecular BiologyPulmonary Alveolar Proteinosis +24

Convection-enhanced delivery of nanoencapsulated gene locoregionally yielding ErbB2/Her2-specific CAR-macrophages for brainstem glioma immunotherapy

Lin Gao, Chongdeng Shi, Zhenmei Yang, +9

Journal of Nanobiotechnology

Trojan Horse Nanocapsule Enabled In Situ Modulation of the Phenotypic Conversion of Th17 Cells to Treg Cells for the Treatment of Multiple Sclerosis in Mice

Chongdeng Shi, Jing Zhang, Huijun Wang, +14

Advanced Materials

Cell TherapyEngineeringImmunologyImmunologic MechanismBiological Therapy +18

Surficial nano-deposition locoregionally yielding bactericidal super CAR-macrophages expedites periprosthetic osseointegration

Ziyang Li, Shengchang Zhang, Zhipeng Fu, +18

Science Advances

Efficiently restoring the tumoricidal immunity against resistant malignancies via an immune nanomodulator

Chen Chen, Aning Li, Peng Sun, +9

Journal of Controlled Release

NanomedicineCross-protectionTumor ImmunologyImmune EvasionResistant Malignancies +10

Remodeling articular immune homeostasis with an efferocytosis-informed nanoimitator mitigates rheumatoid arthritis in mice

Shengchang Zhang, Ying Liu, Weiqiang Jing, +20

Nature Communications

Intracavitary Spraying of Nanoregulator‐Encased Hydrogel Modulates Cholesterol Metabolism of Glioma‐Supportive Macrophage for Postoperative Glioblastoma Immunotherapy

Yuanmin Dong, Jing Zhang, Yan Wang, +21

Advanced Materials