Joe A. Kaczmarski

Evolution of cyclohexadienyl dehydratase from an ancestral solute-binding protein

Ben E. Clifton, Joe A. Kaczmarski, Paul D. Carr et al. · Nature Chemical Biology · 2018 · 106 citations

Aldehyde Dehydrogenase, Biochemistry, Protein Folding +4

Structures of a non-ribosomal peptide synthetase condensation domain suggest the basis of substrate selectivity

Thierry Izoré, Ying-Ning Ho, Joe A. Kaczmarski et al. · Nature Communications · 2021 · 76 citations · Full text

Kistamicin biosynthesis reveals the biosynthetic requirements for production of highly crosslinked glycopeptide antibiotics

Anja Greule, Thierry Izoré, Dumitrita Iftime et al. · Nature Communications · 2019 · 64 citations · Full text

Altered conformational sampling along an evolutionary trajectory changes the catalytic activity of an enzyme

Joe A. Kaczmarski, Mithun C. Mahawaththa, Akiva Feintuch et al. · Nature Communications · 2020 · 63 citations · Full text

Ancestral Sequence Reconstruction Identifies Structural Changes Underlying the Evolution of <i>Ideonella sakaiensis</i> PETase and Variants with Improved Stability and Activity

Yvonne Joho, Vanessa Vongsouthi, Matthew A. Spence et al. · Biochemistry · 2022 · 60 citations

Ancestral Protein Reconstruction, Improved Stability, Genetics +25