Generation of quinolone antimalarials targeting the <i>Plasmodium falciparum</i> mitochondrial respiratory chain for the treatment and prophylaxis of malaria

Giancarlo A. Biagini, Nicholas Fisher, Alison E. Shone, +29

Proceedings of the National Academy of Sciences

Antimalarial 4(1H)-pyridones bind to the Q _i site of cytochrome <i>bc</i> ₁

Michael J. Capper, Paul M. O’Neill, Nicholas Fisher, +8

Proceedings of the National Academy of Sciences

Cytochrome b Mutation Y268S Conferring Atovaquone Resistance Phenotype in Malaria Parasite Results in Reduced Parasite bc1 Catalytic Turnover and Protein Expression

Nicholas Fisher, Roslaini Abd Majid, Thomas Antoine, +8

Journal of Biological Chemistry

Mitochondrial Cytochrome BcAntiparasitic AgentGeneticsMalariaMolecular Biology +18

HDQ, a Potent Inhibitor of Plasmodium falciparum Proliferation, Binds to the Quinone Reduction Site of the Cytochrome <i>bc</i> ₁ Complex

Cindy Vallières, Nicholas Fisher, Thomas Antoine, +8

Antimicrobial Agents and Chemotherapy

Potent InhibitorAntiparasitic AgentMalariaMolecular BiologyPlasmodium Falciparum +18

Thiazolides as Novel Antiviral Agents. 2. Inhibition of Hepatitis C Virus Replication

Andrew V. Stachulski, Chandrakala Pidathala, Eleanor C. Row, +13

Journal of Medicinal Chemistry

The development of quinoloneesters as novel antimalarial agents targeting the Plasmodium falciparum bc₁protein complex

Robin Neil Cowley, Suet C. Leung, Nicholas Fisher, +8

MedChemComm

Medicinal ChemistrySmall ArrayBioorganic ChemistryGould-jacobs MethodologyBiochemistry +12

Study of the antimalarial activity of 4-aminoquinoline compounds against chloroquine-sensitive and chloroquine-resistant parasite strains

Alexandre S. Lawrenson, David L. Cooper, Paul M. O’Neill, +1

Journal of Molecular Modeling

Molecular Mechanism of Action of Antimalarial Benzoisothiazolones: Species-Selective Inhibitors of the Plasmodium spp. MEP Pathway enzyme, IspD

Kathryn E. Price, Christopher M. Armstrong, Leah S. Imlay, +11

Scientific Reports

Identification of Novel Antimalarial Chemotypes via Chemoinformatic Compound Selection Methods for a High-Throughput Screening Program against the Novel Malarial Target, PfNDH2: Increasing Hit Rate via Virtual Screening Methods

Raman Sharma, Alexandre S. Lawrenson, Nicholas Fisher, +20

Journal of Medicinal Chemistry

Drug TargetBioorganic ChemistryHit IdentificationAntiparasitic AgentMalaria +23

Abacavir Forms Novel Cross-Linking Abacavir Protein Adducts in Patients

Xiaoli Meng, Alexandre S. Lawrenson, Neil G. Berry, +6

Chemical Research in Toxicology

AllergyAutoimmune DiseaseImmunologyAntiviral Drug DevelopmentPathology +11