Structural Characterization of IgG1 mAb Aggregates and Particles Generated Under Various Stress Conditions

Srivalli Telikepalli, Ozan S. Kumru, Cavan Kalonia, +4

Journal of Pharmaceutical Sciences

Structural CharacterizationVarious Stress ConditionsProtein FoldingGlycobiologyImmunology +6

Compatibility, Physical Stability, and Characterization of an IgG4 Monoclonal Antibody After Dilution into Different Intravenous Administration Bags

Ozan S. Kumru, Jun Liu, Junyan A. Ji, +6

Journal of Pharmaceutical Sciences

ImmunohematologyPhysical StabilityImmunocytochemical TechniqueAllergyMedicine +10

Engineered SARS-CoV-2 receptor binding domain improves manufacturability in yeast and immunogenicity in mice

Neil C. Dalvie, Sergio A. Rodriguez‐Aponte, Brittany L. Hartwell, +41

Proceedings of the National Academy of Sciences

Viral PathogenesisImmunologyImmunodominanceViral Structural ProteinBroad-spectrum Vaccines +17

A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates

Payton A. Weidenbacher, Mrinmoy Sanyal, Natalia Friedland, +17

Nature Communications

VaccinationCross-protectionVaccine DevelopmentVaccine TargetImmunology +11

Characterization of the Physical Stability of a Lyophilized IgG1 mAb after Accelerated Shipping-Like Stress

Srivalli Telikepalli, Ozan S. Kumru, Jae Hyun Kim, +6

Journal of Pharmaceutical Sciences

Physical StabilityNatural SciencesLyophilized Igg1 MabMolecular BiologyProtein Engineering +3

Effect of Ionic Strength and pH on the Physical and Chemical Stability of a Monoclonal Antibody Antigen-Binding Fragment

Tingting Wang, Ozan S. Kumru, Yi Li, +6

Journal of Pharmaceutical Sciences

BiochemistryBioanalysisImmunologyChemical StabilityImmunochemistry +8

Calculating the Mass of Subvisible Protein Particles with Improved Accuracy Using Microflow Imaging Data

Cavan Kalonia, Ozan S. Kumru, V. Indira Prajapati, +5

Journal of Pharmaceutical Sciences

EngineeringSubvisible Protein ParticlesMicroscopyMedicineOptical Particle Sizing +10

Radar Chart Array Analysis to Visualize Effects of Formulation Variables on IgG1 Particle Formation as Measured by Multiple Analytical Techniques

Cavan Kalonia, Ozan S. Kumru, Jae Hyun Kim, +2

Journal of Pharmaceutical Sciences

RadarFormulation VariablesMultiple Analytical TechniquesEngineeringSynthetic Aperture Radar +5

Translocation of<i> Borrelia burgdorferi</i> surface lipoprotein OspA through the outer membrane requires an unfolded conformation and can initiate at the C‐terminus

Ryan J. Schulze, Shiyong Chen, Ozan S. Kumru, +1

Molecular Microbiology

Proteinlipid InteractionProtein SecretionProtein FunctionProtein AssemblyBiochemistry +13

Surface Localization Determinants of Borrelia OspC/Vsp Family Lipoproteins

Ozan S. Kumru, Ryan J. Schulze, Mykola V. Rodnin, +2

Journal of Bacteriology