Excitation/inhibition balance and learning are modified by Dyrk1a gene dosage

Benoît Souchet, Fayçal Guedj, Ignasi Sahún, +11

Neurobiology of Disease

Excitation/inhibition BalanceMolecular NeuroscienceSignal TransductionMolecular RegulationMedicine +7

A new mouse model for the trisomy of the Abcg1–U2af1 region reveals the complexity of the combinatorial genetic code of down syndrome

Patricia Lopes Pereira, Laetitia Magnol, Ignasi Sahún, +12

Human Molecular Genetics

Overexpression of Reelin Prevents the Manifestation of Behavioral Phenotypes Related to Schizophrenia and Bipolar Disorder

Cátia M. Teixeira, E. Martin, Ignasi Sahún, +9

Neuropsychopharmacology

Motor phenotypic alterations in TgDyrk1a transgenic mice implicate DYRK1A in Down syndrome motor dysfunction

María Martínez de Lagrán, Xavier Altafaj, Xavier Gallego, +5

Neurobiology of Disease

Down SyndromeKnockout MouseNeurodegenerative DiseasesMolecular NeuroscienceDevelopmental Biology +10

Heterozygous deletion of the Williams–Beuren syndrome critical interval in mice recapitulates most features of the human disorder

María Segura‐Puimedon, Ignasi Sahún, Émilie Velot, +10

Human Molecular Genetics

RESEARCH FOCUS ON COMPULSIVE BEHAVIOUR IN ANIMALS: An animal model of compulsive food‐taking behaviour

Andrea Heyne, Christoph Kiesselbach, Ignasi Sahún, +4

Addiction Biology

Food TakingBehavioral AddictionFood IntakeImpulsivitySocial Sciences +20

Ceramide Levels Regulated by Carnitine Palmitoyltransferase 1C Control Dendritic Spine Maturation and Cognition

Patricia Carrasco, Ignasi Sahún, Jerome J. McDonald, +10

Journal of Biological Chemistry

Targeting Dyrk1A with AAVshRNA Attenuates Motor Alterations in TgDyrk1A, a Mouse Model of Down Syndrome

Jon Ortiz-Abalia, Ignasi Sahún, Xavier Altafaj, +4

The American Journal of Human Genetics

Down SyndromeKnockout MouseDevelopmental BiologyMolecular NeuroscienceSignal Transduction +7

Dissociation between CA3–CA1 Synaptic Plasticity and Associative Learning in TgNTRK3 Transgenic Mice

Ignasi Sahún, José M. Delgado‐García, Alejandro Amador‐Arjona, +4

Journal of Neuroscience

Transgenic mice overexpressing the full-length neurotrophin receptor TrkC exhibit increased catecholaminergic neuron density in specific brain areas and increased anxiety-like behavior and panic reaction

Mara Dierssen, Mónica Gratacòs, Ignasi Sahún, +15

Neurobiology of Disease

Panic ReactionPsychiatryBehavioral NeuroscienceMedicineSpecific Brain Areas +9