Jean–Claude Leunis

The gut-brain barrier in major depression: intestinal mucosal dysfunction with an increased translocation of LPS from gram negative enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression.

Michaël Maes, Marta Kubera, Jean–Claude Leunis · PubMed · 2008 · 619 citations

Dysbiosis, Klebsiella Pneumoniae, Immunology +20

Increased IgA and IgM responses against gut commensals in chronic depression: Further evidence for increased bacterial translocation or leaky gut

Michaël Maes, Marta Kubera, Jean–Claude Leunis et al. · Journal of Affective Disorders · 2012 · 436 citations

Bacterial Translocation, Dysbiosis, Psychiatry +9

Increased serum IgA and IgM against LPS of enterobacteria in chronic fatigue syndrome (CFS): Indication for the involvement of gram-negative enterobacteria in the etiology of CFS and for the presence of an increased gut–intestinal permeability

Michaël Maes, Ivana Mihaylova, Jean–Claude Leunis · Journal of Affective Disorders · 2006 · 203 citations

Dysbiosis, Microbial Disease, Mucosal Immunology +11

Normalization of leaky gut in chronic fatigue syndrome (CFS) is accompanied by a clinical improvement: effects of age, duration of illness and the translocation of LPS from gram-negative bacteria.

Michaël Maes, Jean–Claude Leunis · PubMed · 2008 · 115 citations

Increased IgA responses to the LPS of commensal bacteria is associated with inflammation and activation of cell-mediated immunity in chronic fatigue syndrome

Michaël Maes, Frank Twisk, Marta Kubera et al. · Journal of Affective Disorders · 2011 · 111 citations

Inflammation, Host Response, Autoimmune Disease +12