Metabolic features and regulation in cell senescence

So Mee Kwon, Sun Mi Hong, Young‐Kyoung Lee, +2

BMB Reports

Lactate-mediated mitoribosomal defects impair mitochondrial oxidative phosphorylation and promote hepatoma cell invasiveness

Young‐Kyoung Lee, Jin J. Lim, Un‐woo Jeoun, +5

Journal of Biological Chemistry

MitophagyLactate-mediated Mitoribosomal DefectsMitochondrial FunctionBiochemistryOrganelle Dynamic +8

The Ubiquitin-like with PHD and Ring Finger Domains 1 (UHRF1)/DNA Methyltransferase 1 (DNMT1) Axis Is a Primary Regulator of Cell Senescence

Hyun-Jung Jung, Hae‐Ok Byun, Byul A Jee, +6

Journal of Biological Chemistry

Lactic acidosis caused by repressed lactate dehydrogenase subunit B expression down-regulates mitochondrial oxidative phosphorylation via the pyruvate dehydrogenase (PDH)–PDH kinase axis

Sun Mi Hong, Young‐Kyoung Lee, Imkyong Park, +3

Journal of Biological Chemistry

Lactic AcidosisBiochemistryMitochondrial FunctionNatural SciencesPhysiology +10

Global spliceosome activity regulates entry into cellular senescence

So Mee Kwon, Seongki Min, Un‐woo Jeoun, +7

The FASEB Journal

Lifespan ExtensionAgingSpliceosome SignatureCellular SenescenceSpliceosomal Genes +7

NAMPT mitigates colitis severity by supporting redox-sensitive activation of phagocytosis in inflammatory macrophages

Sun Mi Hong, A‐Yeon Lee, Sung‐Min Hwang, +13

Redox Biology

MRPS31 loss is a key driver of mitochondrial deregulation and hepatocellular carcinoma aggressiveness

Seongki Min, Young‐Kyoung Lee, Jiwon Hong, +4

Cell Death and Disease

Mitochondrial Respiratory Defect Enhances Hepatoma Cell Invasiveness via STAT3/NFE2L1/STX12 Axis

Young‐Kyoung Lee, So Mee Kwon, Eun-beom Lee, +8

Cancers

Mitoribosome Defect in Hepatocellular Carcinoma Promotes an Aggressive Phenotype with Suppressed Immune Reaction

So Mee Kwon, Young‐Kyoung Lee, Seongki Min, +3

iScience

ImmunologyPathologyCell DeathTumor BiologyOxidative Stress +17

Selective targeting of dipeptidyl‐peptidase 4 (DPP‐4) positive senescent chondrocyte ameliorates osteoarthritis progression

Du Hyun Ro, Gun Hee Cho, J. Kim, +8

Aging Cell