NK cells from HCV-infected patients effectively induce apoptosis of activated primary human hepatic stellate cells in a TRAIL-, FasL- and NKG2D-dependent manner

A Glässner, Marianne Eisenhardt, Benjamin Krämer, +5

Laboratory Investigation

HepatologyViral HepatitisLiver PhysiologyMedicineImmunology +11

Natural killer p46High expression defines a natural killer cell subset that is potentially involved in control of hepatitis C virus replication and modulation of liver fibrosis

Benjamin Krämer, Christian Körner, Moritz Kebschull, +7

Hepatology

Compartment-specific distribution of human intestinal innate lymphoid cells is altered in HIV patients under effective therapy

Benjamin Krämer, Felix Goeser, Philipp Lutz, +14

PLoS Pathogens

Lymphocyte DevelopmentInnate Immune SystemImmunologyImmune RegulationPathology +21

Impaired CD4+ T cell stimulation of NK cell anti-fibrotic activity may contribute to accelerated liver fibrosis progression in HIV/HCV patients

A Glässner, Marianne Eisenhardt, P Kokordelis, +8

Journal of Hepatology

Hiv/hcv PatientsHepatologyViral HepatitisLiver PhysiologyHuman Retrovirus +13

Regulatory CD4+ T cells modulate the interaction between NK cells and hepatic stellate cells by acting on either cell type

Bettina Langhans, Abdel Wahed Alwan, Benjamin Krämer, +5

Journal of Hepatology

Autoimmune DiseaseHepatic Stellate CellsMedicineT-regulatory CellImmunology +11

An effective interferon-gamma-mediated inhibition of hepatitis C virus replication by natural killer cells is associated with spontaneous clearance of acute hepatitis C in human immunodeficiency virus-positive patients

P Kokordelis, Benjamin Krämer, Christian Körner, +11

Hepatology

Hepatitis C virus core protein induces fibrogenic actions of hepatic stellate cells via toll-like receptor 2

Martin Coenen, Hans Dieter Nischalke, Benjamin Krämer, +7

Laboratory Investigation

The ratio of calprotectin to total protein as a diagnostic and prognostic marker for spontaneous bacterial peritonitis in patients with liver cirrhosis and ascites

Philipp Lutz, Kenneth Pfarr, Hans Dieter Nischalke, +10

Clinical Chemistry and Laboratory Medicine (CCLM)

The CXCR3(+)CD56Bright Phenotype Characterizes a Distinct NK Cell Subset with Anti-Fibrotic Potential That Shows Dys-Regulated Activity in Hepatitis C

Marianne Eisenhardt, A Glässner, Benjamin Krämer, +7

PLoS ONE

TRAIL receptor I (DR4) polymorphisms C626G and A683C are associated with an increased risk for hepatocellular carcinoma (HCC) in HCV-infected patients

Christian Körner, Katarina Riesner, Benjamin Krämer, +9

BMC Cancer