Agustín Tortajada

Human C3 mutation reveals a mechanism of dense deposit disease pathogenesis and provides insights into complement activation and regulation

Rubén Martínez-Barricarte, Meike Heurich, Francisco Valdés-Cañedo et al. · Journal of Clinical Investigation · 2010 · 220 citations · Full text

Renal Pathology, Immunology, Renal Inflammation +26

C3 glomerulopathy–associated CFHR1 mutation alters FHR oligomerization and complement regulation

Agustín Tortajada, Hugo Yébenes, Cynthia Abarrategui-Garrido et al. · Journal of Clinical Investigation · 2013 · 193 citations · Full text

Glomerular Disease, Renal Pathology, Immunology +23

The disease-protective complement factor H allotypic variant Ile62 shows increased binding affinity for C3b and enhanced cofactor activity

Agustín Tortajada, Tamara Montes, Rubén Martínez-Barricarte et al. · Human Molecular Genetics · 2009 · 132 citations · Full text

Elevated factor H–related protein 1 and factor H pathogenic variants decrease complement regulation in IgA nephropathy

Agustín Tortajada, Eduardo Gutiérrez, Elena Goicoechea de Jorge et al. · Kidney International · 2017 · 114 citations · Full text

Glomerular Disease, Renal Pathology, Immunology +18

Functional basis of protection against age-related macular degeneration conferred by a common polymorphism in complement factor B

Tamara Montes, Agustín Tortajada, B. Paul Morgan et al. · Proceedings of the National Academy of Sciences · 2009 · 106 citations · Full text