Agustín Tortajada

Human C3 mutation reveals a mechanism of dense deposit disease pathogenesis and provides insights into complement activation and regulation

Rubén Martínez-Barricarte, Meike Heurich, Francisco Valdés-Cañedo et al. · Journal of Clinical Investigation · 2010 · 222 citations · Full text

Medicine, Genetics, Pathobiology +17

C3 glomerulopathy–associated CFHR1 mutation alters FHR oligomerization and complement regulation

Agustín Tortajada, Hugo Yébenes, Cynthia Abarrategui-Garrido et al. · Journal of Clinical Investigation · 2013 · 196 citations

Medicine, Molecular Biology, Nephrology +17

The disease-protective complement factor H allotypic variant Ile62 shows increased binding affinity for C3b and enhanced cofactor activity

Agustín Tortajada, Tamara Montes, Rubén Martínez-Barricarte et al. · Human Molecular Genetics · 2009 · 135 citations · Full text

Life Sciences, Genetics, Immunology +14

Elevated factor H–related protein 1 and factor H pathogenic variants decrease complement regulation in IgA nephropathy

Agustín Tortajada, Eduardo Gutiérrez, Elena Goicoechea de Jorge et al. · Kidney International · 2017 · 119 citations · Full text

Medicine, Nephrology, Pathology +17

Functional basis of protection against age-related macular degeneration conferred by a common polymorphism in complement factor B

Tamara Montes, Agustín Tortajada, B. Paul Morgan et al. · Proceedings of the National Academy of Sciences · 2009 · 107 citations · Full text

Life Sciences, Genetics, Ophthalmology +17